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Reduction of postoperative vomiting by preoperative administration of oral metoclopramide

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Preoperative oral metoclopramide was evaluated as a postoperative antiemetic agent.

Two series of approximately one hundred patients were investigated in this context. One series was carefully controlled with regard to anaesthetic agents and technique. The other series had only one criterion of admission-the exclusion of narcotics.

All patients received metoclopramide 20 mg by mouth or a placebo two hours before anaesthesia in a randomized double-blind fashion.

A significant reduction in postoperative symptoms of antiperistalsis was observed in the metoclopramide-treated patients.

On closer scrutiny it became apparent that, under these circumstances, metoclopramide is significantly more effective in males.


Les auteurs ùvaluent à la pùriode post-opùratoire ľactivitù anti-ùmùtique de la mùtoclopramide administrùe par la voie orale avant ľintervention.

Deux groupes de cent malades environ ont ùtù ùtudiùs dans ce but. Ľhomogùnùirù ďun des groupes fut contrôlùe avec soin en ce qui concern ľagent et la technique anesthùsiques.

Ľautre groupe n’avait qu’un critère ďadmission, soit ľabsence de narcotique.

Tous les patients reçurent mùtoclopramide 20 mg per os ou un placebo deux heurs avant ľanesthùsie selon une mùthode randomisùe à double inconnue.

Une diminution significative des symptômes ďantiperistalsisme a ùtù observùe chez les patients traitùs à la mùtroclopramide et plus spùcialement chez ceux du sexe masculin.


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Correspondence to M. J. Diamond or M. Keeri-Szantot.

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Diamond, M.J., Keeri-Szantot, M. Reduction of postoperative vomiting by preoperative administration of oral metoclopramide. Canad. Anaesth. Soc. J. 27, 36 (1980). https://doi.org/10.1007/BF03006846

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  • Metoclopramide
  • Methoxyflurane
  • Antiemetic Effect
  • Postoperative Vomiting
  • Propantheline