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Potassium release following administration of succinylcholine in chronically uraemic monkeys

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Summary

The change in potassium response following succinylcholine was studied in eleven Rhesus monkeys after 10 and 20 days of persistent uraemia. We noted no significant increase in mean potassium levels after administration of succinylcholine in the uraemic groups when contrasted with a control group. However, the serum potassium in one animal rose 1.7 mEq/liter, which is a significant rise (P < 0.05). The potassium response did not change with increasing duration of uraemia, nor did it correlate with either the degree of uraemia nor with the initial potassium value. Since it is impossible to predict under what circumstances an exaggerated response may occur we advise continued caution in the use of succinylcholine in uraemic patients.

Résumé

Sur onze singes Rhesus, maintenus entre 10 et 20 jours en urémie permanente, nous avons étudié les changements des taux de potassium en réponse à ľadministration de succinylcholine. Chez les urémiques comparés aux témoins, nous n’avons pas observé de modifications importantes des taux de potassium aprés ľadministration de succinylcholine. Toutefois, chez un animal, le taux de potassium sérique s’est élevé de 1.7 mEq/litre ce qui constitue une élévation importante (P < 0.05). Cette réponse du potassium n’a pas changé avec la prolongation de ľurémie, pas plus qu’avec ľimportance de ľurémie ou la valeur initiale du potassium. Etant donné qu’il est impossible de prévoir a quel moment il se produira une réponse exagérée du potassium à ľadministration de succinylcholine, nous conseillons une surveillance étroite continuelle des malades urémiques à qui ľon administre de la succénylcholine.

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Correspondence to David R. Cook or A. Benedict Cosimi or Max W. Hammonds.

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Cook, D.R., Cosimi, A.B. & Hammonds, M.W. Potassium release following administration of succinylcholine in chronically uraemic monkeys. Canad. Anaesth. Soc. J. 19, 634–638 (1972). https://doi.org/10.1007/BF03006106

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Keywords

  • Blood Urea Nitrogen
  • Succinylcholine
  • Serum Potassium
  • Potassium Level
  • Uraemic Patient