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The toxicity of sodium nitroprusside

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Résumé

Le nitroprussiate de soude est utilisé comme vasodilatateur puissant chez l’homme depuis 1929. A partir de communications à propos de trois décès reliés au NPS on retient: l’acidose grave et le taux de dosage élevé de nitroprussiate de soude. Ces derniers effets peuvent se rencontrer chez des cas de réponses anormales, non-mortelles au nitroprussiate de soude.

La réponse à l’action du nitroprussiate de soude est l’une des suivantes:

  1. Normale 1.

    vasodilation à bas taux de dosage (<10 µg/kg/min)

  2. Anormale 2.

    vasodilatation à haut taux de dosage (>10µg/kg/min)

  3. 3.

    tachyphylaxie

  4. 4.

    résistance

La manifestation anormale de l’action du nitroprussiate de soude est une des suivantes:

  • -reaction physiologique excessive (rénine-angiotensine-aldostérone), traité par blocage beta ou ganglioplégie;

  • -acidose et accumulation de cyanure de la biotransformation du NPS, traité comme une intoxication au cyanure.

On donne le canduite à suivre pour l’ultilisation súre de nitroprussiate de soude les contre-incations, l’administration du nitroprussiate de soude, la surveillance requise, la conduite à tenir face aux reactions anormales.

References

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Author information

Correspondence to Leila Greiss or N. A. G. Tremblay or D. W. Davies.

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Greiss, L., Tremblay, N.A.G. & Davies, D.W. The toxicity of sodium nitroprusside. Canad. Anaesth. Soc. J. 23, 480 (1976). https://doi.org/10.1007/BF03005976

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Keywords

  • Nitroprusside
  • Sodium Nitroprusside
  • Thiosulphate
  • Abnormal Response
  • Nitroprusside Sodium