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Étude observationnelle SCOPE: suivi sur deux ans d’une cohorte française de patients souffrant d’un trouble schizophrénique ou schizoaffectif; analyse en cluster et taux de rechute

Observational study scope: a two-year follow-up of a french cohort of schizophrenic and schizoaffective patients; cluster analysis at baseline and relapse rates

Résumé

L’objectif principal de l’étude observationnelle SCOPE était d’observer l’évolution sur deux ans d’une cohorte de 833 patients schizophrènes ou schizoaffectifs traités pour un épisode psychotique aigu. Une analyse en cluster a été réalisée à l’inclusion et a permis de mettre en évidence, à partir des paramètres de sexe, âge, diagnostic, durée de la maladie et scores à la CGI gravité et à l’échelle PANSS, l’existence de cinq clusters. Ceux-ci soulignent l’importance des différences liées au sexe et à l’âge dans la schizophrénie ainsi que l’hétérogénéité du trouble schizoaffectif, avec des patients proches de la schizophrénie, d’autres du trouble bipolaire.

Le taux de rechute dans la population totale a été de 32,7% à 2 ans. Les données relatives aux taux de rechute observés dans chaque cluster sont compatibles avec les typologies de patients mises en évidence. L’utilité de cette méthode d’analyse en psychiatrie est particulièrement soulignée par cette étude.

Abstract

The main objective of the SCOPE observational study was to follow-up a cohort of 833 schizophrenic or schizoaffective patients treated for an acute state over a two-year period. A cluster analysis using the Ward method was performed at baseline using gender, age, diagnosis, length of illness, CGI-S and PANSS scores to determine clusters. Five clusters have been identified that underline the importance of gender differences in schizophrenia on one hand, and on the other, the heterogeneity of schizoaffective disorders which include patients near to schizophrenia, while other patients seem to belong to the bipolar spectrum. The two-year relapse rate in the total population was 32.7%. Data concerning relapse rates within each cluster are in line with the patient’s typology. Our results lend support to the validity of this method of analysis in psychiatry.

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Correspondence to Jean-Michel Azorin.

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Azorin, J., Chartier, F., Olivier, V. et al. Étude observationnelle SCOPE: suivi sur deux ans d’une cohorte française de patients souffrant d’un trouble schizophrénique ou schizoaffectif; analyse en cluster et taux de rechute. Psychiatr Sci Hum Neurosci 3, 143–149 (2005). https://doi.org/10.1007/BF03005834

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Mots-Clés

  • Étude observationnelle
  • Analyse en cluster
  • Schizophrénie
  • Trouble schizoaffectif

Keywords

  • Observational study
  • Cluster analysis
  • Schizophrenic disorders
  • Schizoaffective disorders
  • Relapse rate