Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

An analysis of some sensitizing agents in the pathogenesis of stress-induced gastric erosive disease

  • 16 Accesses

Abstract

Prior surgical implantation of a venous catheter sensitized rats to coldimmobilization stress. Three of six catheterized females succumbed during the stress. The remaining rats fell into two groups in terms of their core temperature at the end of the stress period: Male uncatheterized rats had higher temperatures than rats in the other three groups. No relation was found between catheter patency and magnitude of hypothermia. Degree of gastric disease paralleled the core temperature findings in that the male uncatheterized rats had significantly fewer gastric erosions than the rats in the other three groups. Additionally, a robust effect of gender was found with uncatheterized females showing more hypothermia and more gastric disease than uncatheterized males. A subsequent experiment was conducted to evaluate whether anesthesia or wearing the protective spring was responsible in part for the sensitization seen. Here, the gender difference was less although females consistently averaged lower core temperatures after stress than did males. Despite similar core temperatures after stress, females that were prepared with the protective spring apparatus developed more gastric disease than female controls or similarly treated males. Thus, the additional sensitization exhibited by females in the first experiment may relate to the fact that both catheterization and the taping procedure were sensitizers while only catheterization was a sensitizer for males.

This is a preview of subscription content, log in to check access.

References

  1. Ader, R., Beels, C. C., and Tatum, R. Blood pepsinogen and gastric erosions in the rat.Psychosomatic Medicine, 1960,22, 1–12.

  2. Antoon, J. W., and Gregg, R. V. The influence of body temperature on the production of ulcers of restraint in the rat.Gastroenterology, 1976,70, 747–750.

  3. Brodie, D. A., and Valitski, L. S. Production of gastric hemorrhage in rats by multiple stresses.Proceedings of the Society for Experimental Biology and Medicine, 1963,113, 998–1001.

  4. Glavin, G. B. Restraint ulcer: History, current research and future implications. In M. I. Grossman, and D. Novin (Eds.),Experimental Ulcer Produced By Behavioral Factors. Brain Research Bulletin, 1980,5 Supplement 1, 51–58.

  5. Kim, Y. S., and Lambooy, J. P. Riboflavin deficiency and gastric ulcer production in rat: A procedure for the study of susceptibility to stress-induced gastric ulcers.Journal of Nutrition, 1967,91, 183–188.

  6. Natelson, B. H., Janocko, L., and Jacoby, J. H. An interaction between dietary tryptophan and stress in exacerbating gastric disease.Physiology and Behavior, 1981,26, 197–200.

  7. Robert, A., Phillips, J. P., and Nezamis, J. E. Production, by restraint, of gastric ulcers and of hydrothorax in the rat.Gastroenterology, 1966,51, 75–81.

  8. Sawrey, W. L., and Long, D. H. Strain and sex differences in ulceration in the rat.Journal of Comparative and Physiological Psychology, 1962,4, 603–605.

  9. Sines, J. O. Strain differences in activity, emotionality, body weight and susceptibility to stress induced stomach lesions.Journal of Genetic Psychology, 1962,101, 209–217.

  10. Tran, T. A., and Gregg, R. V. Hypothermia in restraint-induced gastric ulcers in parabiotic rats.Gastroenterology, 1974,67, 271–275.

  11. Wilson, T. R. Age and susceptibility to gastric ulceration in male and female rats.Gerontologia, 1966,12, 226–230.

  12. Wilson, T. R. Strain and sex differences in gastric ulceration in restrained rats.Acta Geneticae Medicae et Gemollologie, 1967,16, 310–316.

  13. Wilson, T. R. Monthly variations in the severity of experimental stress ulcers in rats. In C. J. Pfeiffer (Ed.),Peptic Ulcer. Philadelphia: J. B. Lippincott, 1971, pp. 110–117.

Download references

Author information

Correspondence to B. H. Natelson.

Additional information

Supported by VA medical research funds and by contract no. DAMD17-80-C-0166 from the U.S. Army.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Natelson, B.H., Ferrara-Ryan, M., Creighton, D. et al. An analysis of some sensitizing agents in the pathogenesis of stress-induced gastric erosive disease. Pav. J. Biol. Sci. 19, 195–199 (1984). https://doi.org/10.1007/BF03004517

Download citation

Keywords

  • Core Temperature
  • Gastric Disease
  • Gastric Erosion
  • Taping Procedure
  • Catheter Patency