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Effects of pentobarbital and meperidine on canine cerebral and total oxygen consumption rates

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The individual effects of two premedicant drugs, pentobarbital and meperidine, on both total-body oxygen consumption ( Vo2 ) and cerebral oxygen consumption ( CMRo2 ) rates were studied in dogs during light halothane anaesthesia. Vo2 was measured by means of a modified closed-circuit spirometry apparatus. CMRo2 was calculated from the difference between arterial and sagittal-sinus oxygen content and from the directly measured cerebral blood flow. Pentobarbital decreased Vo2 by 7 per cent and CMRo2 by 10 per cent. Meperidine had no effect on Vo2, but decreased CMR02 by 13 per cent. These findings are discussed in relation to previous reports of the effects of preanaesthetic medication on Vo2 in man and current concepts of the relationship between cerebral metabolism and function.


Au cours ďune anesthésie légère à ľhalothane, nous avons étudié les effets individuels de deux médicaments employés en prémédication, le pentobarbital et la mépéridine, effets à la fois sur la Vo2 et le CMRo2. Nous avons mesuré la Vo2 à ľaide ďun appareil modifié de spirométrie en circuit fermé. Le CMRo2 a été calculé ďaprès la différence entre le contenu en oxygène du sang artériel et du sinus sagittal et la mesure directe du débit sanguin cérébral. Le pentobarbital diminue de 7 pour cent la Vo2 et, de 10 pour cent, le CMRo2. La meperidine n’a pas ďeffet sur la Vo2 mais elle diminue de 13 pour cent le CMRo2. Nous discutons ces résultats en songeant à des études antérieures sur les effets de la prémédication anesthésique sur la Vo2 chez ľhomme et les théories récentes concernant les rapports entre le métabolisme cérébral et les fonctions cérébrales.


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Correspondence to Joseph M. Messick or Richard A. Theye.

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Messick, J.M., Theye, R.A. Effects of pentobarbital and meperidine on canine cerebral and total oxygen consumption rates. Can. Anaes. Soc. J. 16, 321–330 (1969). https://doi.org/10.1007/BF03004461

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  • Halothane
  • Mean Arterial Pressure
  • Pentobarbital
  • Meperidine
  • Oxygen Consumption Rate