Canadian Anaesthetists’ Society Journal

, Volume 14, Issue 2, pp 79–86 | Cite as

Ventricular arrhythmias induced by aminophylline during halothane anaesthesia in dogs

  • Masuhiko Takaori
  • Robert W. Loehning


Intravenous administration of aminophylline to dogs anaesthetized with 1 per cent halothane resulted in ventricular arrhythmias in 12 of 16 animals ( ventricular fibrillation in three animals). Halothane-aminophylline arrhythmias disappeared when the animals were ventilated with 3 per cent halothane but reappeared when the animals were subsequently ventilated with room air. Arrhythmias did not occur when aminophylline was given to animals ventilated with 3 per cent halothane or to dogs anaesthetized with pentobarbital. Following administration of aminophylline one out of ten unanaesthetized dogs and two of six animals ventilated with 3 per cent ether developed short periods of multifocal premature ventricular contractions. A possible explanation of the data obtained is presented.


Halothane Ventricular Arrhythmia Ventricular Fibrillation Aminophylline Premature Ventricular Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


L’administration d’aminophylline par voie endoveineuse à des chiens anesthésiaséavec 1 pour cent de fluothane a entrainé des arythmies ventriculaires chez 12 des 16 animaux et une fibrillation ventriculaire, chez trois. Les arythmies fluothaneaminophylline sont disparues lorsque, subséquemment, nous avons ventilé les animaux avec l’air de la pièce. Nous n’avons pas observé d’arythmies lorsque nous avons donné l’aminophylline à des animaux ventilés avec 3 pour cent d’halothane ou à des chiens anesthésiées avec du pentobarbital. A la suite de l’administration d’aminophylline un sur dix des chiens non anesthésiés et deux sur six des animaux ventilés avec 3 pour cent d’éther ont présenté de courtes périodes de contractions ventriculaires prématurées multifocales. Nous présentons une explication possible des résultats obtenus.


  1. 1.
    Wylie, W. D. &Churchill-Davidson, H. C. A Practice of Anaesthesia. 1st ed., Chicago: Year Book Publishers Inc. (1961), p. 28.Google Scholar
  2. 2.
    Evans, F. T. &Gray, C. General Anaesthesia, vol. 2. 1st ed., London: Butterworth & Co. (1959), p. 337.Google Scholar
  3. 3.
    Artusio, J. F. &Mazzia, V. D. B. Practical Anesthesiology. 1st ed., St. Louis: C. V. Mosby Co. (1962), p. 224.Google Scholar
  4. 4.
    Converse, J. G. &Smotrilla, M. M. Anesthesia and the Asthmatic. Anesth. & Analg. 40:336 (1961).Google Scholar
  5. 5.
    Shnider, S. M. &Papper, E. M. Anesthesia for the Asthmatic Patient. Anesthesiology. 22:886 (1961).PubMedCrossRefGoogle Scholar
  6. 6.
    Mezzasalma, G. Spunti Patogenetic Sulle Aritmie Sperimental da Caffeina-Adrenalina. Boll. Soc. Ital. Biol. Sper. 32: 1637 (1956).PubMedGoogle Scholar
  7. 7.
    Ueda, I.;Loehning, R. W.; &Ueyama, H. Relationship Between Sympathomimetic Amines and Methylxanthines Inducing Cardiac Arrhythmias. Anesthesiology 22: 926 (1961).PubMedCrossRefGoogle Scholar
  8. 8.
    Barach, A. L. Remissions in Bronchial Asthma and Hypertrophic Pulmonary Emphysema. J.A.M.A. 147:730(1951).Google Scholar
  9. 9.
    Gay, L. N. The Diagnosis and Treatment of Bronchial Asthma. Baltimore: Williams & Wilkins Co. (1946), p. 197.Google Scholar
  10. 10.
    Abramson, H. A. Treatment of Asthma. Baltimore: Williams & Wilkins Co. (1951), p. 161.Google Scholar
  11. 11.
    Takaori, M. &Loehning, R. W. Ventricular Arrhythmias during Halothane Anesthesia: Effect of Isoproterenol, Aminophylline, and Ephedrine. Canad. Anaesth. Soc. J. 12: 275 (1965).PubMedCrossRefGoogle Scholar
  12. 12.
    Sollman, T. A Manual of Pharmacology. 8th ed., Philadelphia: Saunders (1957), p. 258.Google Scholar
  13. 13.
    Hardman, H. F. Molecular Form of Theophylline Responsible for Inotropic Activity. Circulation Res. 10: 598 (1962).PubMedGoogle Scholar
  14. 14.
    Daweke, H. &Becker, G. Die Wirkung von Sympathicomimetica in Kombination mit Xanthinderivaten am isolierten Meershweinchenherzen nach Lagendorff. Arch. Int. Pharmacodyn. 122: 357 (1959).PubMedGoogle Scholar
  15. 15.
    Price, H. L.;Linde, H. W.;Jones, R. E.;Black, G. W.; &Price, M. L. Sympathoadrenal Responses to General Anesthesia in Man and Their Relation to Hemodynamics. Anesthesiology. 20: 563 (1959).PubMedCrossRefGoogle Scholar
  16. 16.
    Hamelber G. W.;Sprouse, J. H.;Mahaffey, J. E.; &Richardson, J. A. Catechol Levels during Light and Deep Anesthesia. Anesthesiology. 21: 297 (1960).CrossRefGoogle Scholar
  17. 17.
    Millar, R. A. &Morris, M. E. Sympatho-adrenal Responses during General Anesthesia in the Dog and Man. Canad. Anaesth. Soc. J. 8: 356 (1961).PubMedGoogle Scholar
  18. 18.
    Nayler, W. G. The Action of Fluothane, Chloroform, and Hypothermia on the Heart. Austr. J. Exp. Biol. Med. Sci. 37: 279 (1959).CrossRefGoogle Scholar
  19. 19.
    Black, G. W. &Mcardle, L. The Effects of Halothane on the Peripheral Circulation in Man. Brit. J. Anaesth. 34: 2 (1962).PubMedCrossRefGoogle Scholar
  20. 20.
    Price, M. L. &Price, H. L. Effect of General Anesthetics on Contractile Responses of Rabbit Aortic Strips. Anesthesiology. 23: 16 (1962).PubMedCrossRefGoogle Scholar
  21. 21.
    Riker, W. F.;DePierre, F.;Roberts, J.;Roy, B. B.; &ReBlly, J. The Epinephrine and Hydrocarbon-epinephrine Disturbance in the Cat. J. Pharmacol. & Exp. Therap. 114: 1(1955).Google Scholar
  22. 22.
    Mum, B. J.;Hall, L. W.; &Littleworth, M. C. G. Cardiac Irregularities in Cats under Halothane Anaesthesia. Brit. J. Anaesth. 31: 488 (1959).CrossRefGoogle Scholar
  23. 23.
    Purchase, I. F. H. Cardiac Arrhythmias Occurring during Halothane Anaesthesia in Cats. Brit. J. Anaesth. 38: 13 (1966).PubMedCrossRefGoogle Scholar
  24. 24.
    Johnstone, M. Halothane: The First Five Years. Anesthesiology. 22: 591 (1961).PubMedCrossRefGoogle Scholar
  25. 24.
    Black, G. W.;Linde, H. W.;Dripps, R. D.; &Price, H. L. Circulatory Changes Accompanying Respiratory Acidosis during Halothane Anaesthesia in Man. Brit. J. Anaesth. 31:238 (1959).PubMedCrossRefGoogle Scholar
  26. 26.
    Moe, G. K.;Malton, S. D.;Rennick, B. R.; &Freyburger, W. A. Role of Arterial Pressure in Induction of Idioventricular Rhythms under Cyclopropane Anesthesia. J. Pharmacol. & Exp. Therap. 93: 319 (1948).Google Scholar
  27. 27.
    Dresel, P. E.;MacCannell, K. L.; &Nickerson, M. Cardiac Arrhythmias Induced by Minimal Doses of Epinephrine in Cyclopropane-Anesthetized Dogs. Circulation Res. 8: 948 (1960).PubMedGoogle Scholar
  28. 28.
    CummIngs, J. R. &Hays, W. Cardiovascular Studies of Adrenergic and Ganglionic Stimulating Drugs Administered during Cyclopropane. Anesthesiology. 17: 314 (1956).PubMedCrossRefGoogle Scholar
  29. 29.
    Nickerson, M. &Nomaguchi, G. Mechanism of Dibenamine Protection against Cyclopropane-Epinephrine Cardiac Arrhythmias. J. Pharmacol. Exper. Therap. 95: 1 (1949).Google Scholar
  30. 30.
    Siebecker, K. L.;Bamforth, B. J.;Kraemer, R.; &Orth, O. S. Ventricular Tachycardia Produced by Metaraminol during Cyclopropane Anesthesia in Dogs. Anesthesiology. 22: 555 (1961).CrossRefGoogle Scholar

Copyright information

© Canadian Anesthesiologists 1967

Authors and Affiliations

  • Masuhiko Takaori
    • 1
  • Robert W. Loehning
    • 1
  1. 1.Division of Anesthesiology, College of MedicineUniversity of UtahSalt Lake City

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