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Canadian Anaesthetists’ Society Journal

, Volume 14, Issue 2, pp 79–86 | Cite as

Ventricular arrhythmias induced by aminophylline during halothane anaesthesia in dogs

  • Masuhiko Takaori
  • Robert W. Loehning
Article

Summary

Intravenous administration of aminophylline to dogs anaesthetized with 1 per cent halothane resulted in ventricular arrhythmias in 12 of 16 animals ( ventricular fibrillation in three animals). Halothane-aminophylline arrhythmias disappeared when the animals were ventilated with 3 per cent halothane but reappeared when the animals were subsequently ventilated with room air. Arrhythmias did not occur when aminophylline was given to animals ventilated with 3 per cent halothane or to dogs anaesthetized with pentobarbital. Following administration of aminophylline one out of ten unanaesthetized dogs and two of six animals ventilated with 3 per cent ether developed short periods of multifocal premature ventricular contractions. A possible explanation of the data obtained is presented.

Keywords

Halothane Ventricular Arrhythmia Ventricular Fibrillation Aminophylline Premature Ventricular Contraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

RÉsumÉ

L’administration d’aminophylline par voie endoveineuse à des chiens anesthésiaséavec 1 pour cent de fluothane a entrainé des arythmies ventriculaires chez 12 des 16 animaux et une fibrillation ventriculaire, chez trois. Les arythmies fluothaneaminophylline sont disparues lorsque, subséquemment, nous avons ventilé les animaux avec l’air de la pièce. Nous n’avons pas observé d’arythmies lorsque nous avons donné l’aminophylline à des animaux ventilés avec 3 pour cent d’halothane ou à des chiens anesthésiées avec du pentobarbital. A la suite de l’administration d’aminophylline un sur dix des chiens non anesthésiés et deux sur six des animaux ventilés avec 3 pour cent d’éther ont présenté de courtes périodes de contractions ventriculaires prématurées multifocales. Nous présentons une explication possible des résultats obtenus.

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Copyright information

© Canadian Anesthesiologists 1967

Authors and Affiliations

  • Masuhiko Takaori
    • 1
  • Robert W. Loehning
    • 1
  1. 1.Division of Anesthesiology, College of MedicineUniversity of UtahSalt Lake City

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