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Nylidrin HCL: A beta-sympathetic stimulant in the management of haemorrhagic shock

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Summary

In the assessment of classical haemorrhagic shock in twenty-two dogs, thirteen of them treated with Nylidrin HC1, ten survived extended episodes of arterial hypotension down to a mean arterial pressure of 40 mm.Hg. Of nine control animals (untreated), five survived the re-infusion period. In the course of our study, Nylidrin HC1 displayed two important pharmacodynamic effects:

  1. 1.

    It stimulated peripheral tissue arterial inflow, thus assisting metabolic exchange and reducing the peripheral anoxia of circulatory failure which aggravates metabolic acidosis.

  2. 2.

    It significantly increased cardiac output. Nylidrin HC1 improves myocardial contractility and reduces peripheral arterial resistance. Slight increases in cardiac rate were also noted, along with a moderate decrease in arterial blood pressure. However, neither change proved to be statistically significant. Both groups were compared during and after shock to evaluate contributions to therapy afforded by a Beta stimulatory sympathomimetic. agent.

Résumé

Les résultats de cette étude sur le choc hémorragique chez vingt-deux chiens ont démontré que dix d’entre eux, traités par l’hydrochlorure de Nylidrin (77%), ont survécu des épisodes d’hypotension artérielle sévère de 40 mm.Hg (moyenne). Du groupe témoin composé de neuf chiens, cinq ont survécu sans traitement. Dans notre 6tude, ce médicament a eu deux actions pharmaco-dynamiques importantes:

  1. 1.

    D’augmenter le débit sanguin capillaire périphérique, tout en augmentant les échanges métaboliques et diminuant l’anoxie stagnante prolongéed qui aggrave l’acidose métabolique.

  2. 2.

    II augmente le débit cardiaque de façon significative. L’hydrochlorure de Nylidrin augmente la contractilité du myocarde et diminue la resistance artérielle périphérique. L’on note aussi qu’il y a une légère augmentation du pouls cardiaque et une légère diminution de la tension artérielle moyenne; toutefois, ces changements ne se sont avérés que peu significatifs. Les deux groupes ont été comparés avant, pendant et après le choc hémorragique pour éValuer l’action thérapeutique d’un agent bêta-sympathomimétique.

References

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Correspondence to Guy M. Boiteau.

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Boiteau, G.M., Dechêne, J. Nylidrin HCL: A beta-sympathetic stimulant in the management of haemorrhagic shock. Can. Anaes. Soc. J. 13, 252 (1966). https://doi.org/10.1007/BF03003548

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Keywords

  • Cardiac Output
  • Blood Volume
  • Arterial Blood Pressure
  • Metabolic Acidosis
  • Total Peripheral Resistance