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Blood buffer values in mineral deficiency

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Conclusions

  1. 1.

    The buffer values of serum obtained from normal and rachitic infants have been determined electrometrically for the entire pH range.

  2. 2.

    The blood buffer curves of normal and rachitic infants plotted against that of a non-buffered solution show the marked diminution in the blood buffer capacity in rickets.

  3. 3.

    The buffer action of blood is not constant but is determined by the pH at which it reacts.

  4. 4.

    The buffer capacity of normal serum is greater on the alkaline side than it is on the acid side within the biological range of pH 5 to 8.5, beyond which the buffer values of serum become markedly accentuated.

  5. 5.

    The diminished buffer capacity of the serum of rachitic infants at all pH ranges explains the relative instability of the acid-base mechanism in rickets.

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References

  1. 1.

    Kugelmass, I. N.:J. Biol. Chem., 60, 237, 1924.

  2. 2.

    Kugelmass, I. N.:Am. J. Dis. Children, 39, 687, 1930.

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Author information

Correspondence to I. Newton Kugelmass M.D..

Additional information

From the Heckscher Institute, New York City.

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Kugelmass, I.N. Blood buffer values in mineral deficiency. American Journal of Digestive Diseases and Nutrition 2, 730–732 (1935). https://doi.org/10.1007/BF03002438

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Keywords

  • Buffer Capacity
  • Rickets
  • Alkaline Side
  • Marked Diminution
  • Electrometric Titration