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A comparison of the action of meperidine and diazepam in anaesthetic premedication

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The premedicant action of diazepam was compared with meperidine in a double-blind study involving 160 patients. Sixty patients underwent D & C; the other 100 had laparotomies.

The results indicate that satisfactory premedication can be obtained in most patients by prescribing the drugs at 0700 hours regardless of the hour of surgery.

The two compounds produced no statistically significant difference in any of the major parameters by which the success of premedication could be judged. What difference was observed, however, tended to favour diazepam.


Chez 160 patients (60 curettages utérins et 100 laparotomies), nous avons comparé, à double insu, les effets d’une médication pré-anesthésique au diazepam et à la mépéridine.

Les résultats obtenus avec Tun et l’autre de ces médicaments ont été, pour la plupart de ces patients, comparables et satisfaisants, selon les paramétres dévaluation d’une médication pré-anesthésique. Cependant, quelques comparaisons sans signification statistique, semblent en faveur du diezepam.

Nous avons observé par ailleurs d’aussi bons effets de ces deux médications données à 7 a.m., quelle que fût l’heure de l’opération.


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Correspondence to A. Cormier or M. Goyette or M. Keé ri-Szántó or J. Rheault.

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Cormier, A., Goyette, M., ri-Szántó, M.K. et al. A comparison of the action of meperidine and diazepam in anaesthetic premedication. Can. Anaes. Soc. J. 13, 368–373 (1966). https://doi.org/10.1007/BF03002178

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  • Diazepam
  • Halothane
  • Thiopental
  • Meperidine
  • Innovar