Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

A comparison of the action of meperidine and diazepam in anaesthetic premedication

  • 173 Accesses

  • 10 Citations

Summary

The premedicant action of diazepam was compared with meperidine in a double-blind study involving 160 patients. Sixty patients underwent D & C; the other 100 had laparotomies.

The results indicate that satisfactory premedication can be obtained in most patients by prescribing the drugs at 0700 hours regardless of the hour of surgery.

The two compounds produced no statistically significant difference in any of the major parameters by which the success of premedication could be judged. What difference was observed, however, tended to favour diazepam.

RéSUMé

Chez 160 patients (60 curettages utérins et 100 laparotomies), nous avons comparé, à double insu, les effets d’une médication pré-anesthésique au diazepam et à la mépéridine.

Les résultats obtenus avec Tun et l’autre de ces médicaments ont été, pour la plupart de ces patients, comparables et satisfaisants, selon les paramétres dévaluation d’une médication pré-anesthésique. Cependant, quelques comparaisons sans signification statistique, semblent en faveur du diezepam.

Nous avons observé par ailleurs d’aussi bons effets de ces deux médications données à 7 a.m., quelle que fût l’heure de l’opération.

References

  1. 1.

    Brandt, A. L. &Oakes, F. D. Preanesthesia Medication: Double-Blind Study of a New Drug, Diazepam. Anesth. & Analg. Curr. Res.44: 125 (1965).

  2. 2.

    Tornetta, F. J. Diazepam as Preanesthetic Medication: A Double-Blind Study. Anesth. & Analg. Curr. Res.44: 449 (1965).

  3. 3.

    Sadove, M. S.;Balagot, R. C.; &McGrath, J. M. Effect of Chlordiazepoxide and Diazepam on the Influence of Meperidine on the Respiratory Response to Carbon Dioxide. J. New Drugs.5: 121 (1965).

  4. 4.

    Pierce, J. A. &Garofalo, M. L. Preoperative Medication and Blood Gases. J.A.M.A.194:487(1965).

  5. 5.

    Keeri-Szanto, M. &Labarre, J. Buthalitone Sodium Anesthesia: Drug-Consumption and Serum Protein Studies. Canad. Anaesth. Soc. J.4: 338 (1957).

  6. 6.

    Audet, J.;Beaudoin, G.;Keéri-Szántó, M.; &Trop, D. Halogenated Anesthetics and Innovar: A Comparative Liver Function Study. Third World Congress of Anes., São Paulo, Vol. II, 78–85 (1964).

  7. 7.

    Rogers, S. P. Clinical Observations of Diazepam a New Muscle Relaxant. Western Med.4: 51 (1963).

Download references

Author information

Correspondence to A. Cormier or M. Goyette or M. Keé ri-Szántó or J. Rheault.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cormier, A., Goyette, M., ri-Szántó, M.K. et al. A comparison of the action of meperidine and diazepam in anaesthetic premedication. Can. Anaes. Soc. J. 13, 368–373 (1966). https://doi.org/10.1007/BF03002178

Download citation

Keywords

  • Diazepam
  • Halothane
  • Thiopental
  • Meperidine
  • Innovar