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Autoimmunity, central axonal regeneration and Cyclosporine-A. In vitro observations on the action mechanisms

Autoimmunità, rigenerazione del sistema assonale centrale e ciclosporina A. Osservazioni in vitro sul meccanismo di azione

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Previous observations made by us showed administration of cyclosporine-A (CyA) in rats with traumatic lesions of the spinal cord induces the regeneration of a considerable portion of the spinal fibres, accompanied by functional recovery of varying degrees. The study of the action of this drug on the differentiation of cellular lines of neuronal origin and proteases has excluded the possibility that this effect may be due to any collateral CyA activity other than the clearly immunosuppressive one it has. These results promote further coniirmation of our autoimmunitary theory on the absence of central axonal regeneration in Mammals.


Precedenti nostre osservazioni hanno dimostrato che 1a somministrazione di ciclosporina A (CyA) induce in ratti midollolesi 1a rigenerazione morfologica di una considerevole parte del1e fibre spinaii, con ripristino in vario grado dé lia funzionalità. Lo studioin vitro dell’azione del farmaco sul differenziamento di linee cellulari di derivazione neuronale e sulle proteasi ha permesso di escludere che tale effetto sia riconducibile ad attività collaterali della CyA diverse dalla sua perspicua azione immunosoppressiva. Si avvalora pertanto 1a nostra teoria autoimmunitaria sulla mancata rigenerazione assonale centrale nei Mammiferi.

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Correspondence to Cinzia Fabrizi or Brunella Caronti or Guido Palladini.

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Nella seduta del 3 novembre 1994.

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Fabrizi, C., Caronti, B. & Palladini, G. Autoimmunity, central axonal regeneration and Cyclosporine-A. In vitro observations on the action mechanisms. Rend. Fis. Acc. Lincei 6, 87–93 (1995). https://doi.org/10.1007/BF03001636

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Key words

  • Autoimmunity
  • Central axonal regeneration
  • Mammals
  • Cyclosporin-A