The average normal gastric emptying time was determined fluoroscopically in four healthy young adults. The test meal consisted essentially of 15 grams of Quaker Farina cooked in water to a constant volume of 200 cc. Fifty grams of barium sulfate were added so the position of the meal could be determined. Four determinations were made on each subject and the average figure used for the norm.
A therapeutic dose (6% grs., 0.42 gm.) of dehydro-cholic acid was administered in 100 cc. of water ten minutes before the test meal was eaten and the gastric emptying time again determined. The average decrease in the gastric emptying time in the 4 individuals was 21.2 per cent. The extremes ranged from 14.2 to 33.3 per cent. When analyzed, the results showed a high degree of statistical significance.
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This research was made possible through a grant from the Therapeutic Research Committee of the Council on Pharmacy and Chemistry of the American Medical Association.
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Liere, E.J.V., Northup, D.W. The emptying time of the normal human stomach after the administration of a bile preparation. Jour. D. D. 8, 26–27 (1941). https://doi.org/10.1007/BF02999390
- Test Meal
- Cholic Acid
- Gastric Motility
- Gradient Theory
- Barium Sulfate