Experimental obstruction of the upper portion of the jejunum by a soft ligature in rabbits resulted in an increase in the blood hematocrit of 23 to 40 per cent in 6 of 8 animals. The increase in the other two was 5 and 10 per cent but their total volume of red cells decreased. There was no visible sign of hemolysis in the serum of any of the rabbits.
The plasma volume decreased in all animals, the percentage decrease ranging from 23 to 29 per cent.
The volume of extra-cellular fluid outside of the circulating blood stream decreased, with one exception, 19 to 34 per cent below the normal. The data of one animal clearly showed the movement of tissue fluid into the blood stream after some hemoconcentration had been attained. In Rabbit 3, tissue fluid apparently did not significantly move into the blood stream.
Other evidence of circulatory failure, was the apparent cyanosis, blanched, cold skin of the ear, poor cutaneous, hyperemic response to stimuli and inability to withstand removal of a small volume of blood.
It is concluded that the loss of sodium, chloride and water into the obstructed bowel of rabbits leads to a reduction of plasma and tissue fluid volumes, with the accompanying circulatory failure.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Bunting, C. H. and Jones, A. P. Intestinal obstruction in the rabbit. J. Exper. Med. 17, 192 (1913) and 18, 25, (1913).
Gamble, J. L. and McIver, M. A. A study of the effects of pyloric obstruction in rabbits. J. Clin. Invest. 1, 531 (1925).
Raine, F. and Perry, M. C. Intestinal obstruction. Arch. Surg. 19, 478 (1929).
Herrin, R. C. and Meek, W. J. Distention as a factor in intestinal obstruction. Arch. Int. Med. 51, 152 (1933).
Aird, I. The behavior of the blood volume in intestinal obstruction and strangulation. Brit. J. Surg. 26, 418 (1938).
Gendel, S. and Fine, J. The effect of acute intestinal obstruction on the blood and plasma volumes. Ann. Surg. 110, 25 (1939).
Fine, J., Hurwitz, A. and Marks, J. A clinical study of the plasma volume in acute intestinal obstruction. Ann. Surg. 112, 546 (1940).
Abbott, W. E., Mellors, R. C. and Muntwyler, E. Fluid, protein and electrolyte alterations in experimental intestinal obstruction. Ann. Surg. 117, 39 (1943).
Crandall, L. A. and Anderson, M. X. The estimation of the state of hydration of the body by the amount of water available for the solution of sodium thiocyanate. Am. J. Dig. Dis. and Nutrition 1, 126 (1934).
Gibson, J. G. and Evelyn, K. A. Clinical studies of blood volume. Adaptation of the method to the photoelectric microcolorimeter. J. Clin. Invest. 17, 153 (1938).
Moon, V. H. Shock and Related Capillary Phenomena. Oxford University Press. New York, 1938.
Haden, R. L. and Orr, T. G. The oxygen content of the venous blood of the dog after upper gastrointestinal tract obstruction. J. Exp. Med. 46, 709 (1927).
Herrin, R. C. Chemical changes in blood and intestinal juice produced by the loss of intestinal juice. J. Biol. Chem. 108, 547 (1935).
Besser, E. L. Causes of death in cases of mechanical intestinal obstruction. Arch. Surg. 41, 970 (1940).
Dragstedt, L. R. and Ellis, J. C. The fatal effect of the total loss of gastric juice. Am. J. Physiol. 93, 407 (1930).
Taylor, N. B., Weld, C. B. and Harrison, G. K. Experimental intestinal obstruction. Canad. M. A. J. 29, 236 (1933).
Gamble, J. L. and Ross, S. G. The factors in the dehydration following pyloric obstruction. J. Clin. Invest. 1, 403 (1925).
About this article
Cite this article
Ender, C.A., Herrin, R.C. Changes in the volumes of blood and extra-cellular fluid in bowel obstruction of the rabbit. Jour. D. D. 12, 193–196 (1945). https://doi.org/10.1007/BF02998442
- Intestinal Obstruction
- Bowel Obstruction
- Plasma Volume
- Circulatory Failure