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The effect of certain parenterally administered drugs on the Colon of the Dog

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Summary and Conclusions

A series of experiments were performed on trained unanesthetized dogs having Thiry or Vella colonic fistulas in order to determine the effect of a number of drugs on the motility of the colon. The drugs were administered parenterally. Recordings were obtained by means of rubber balloons and also by means of a constant pressure apparatus. It was found that calcium salts, physostigmine, hypertonic solutions of sodium chloride and acetylcholine produced increased tone and increased motility. Pitocin, pituitrin, pitressin, ephedrine, histamine and epinephrine caused decreased tone and decreased motility. Pitocin produced the most striking depressive effect. Hypertonic solutions of glucose and parathyroid extract had little or no effect on colonic motility. Physostigmine, used in combination with ephedrine, produced very marked stimulation of colonic motility, as did the use of physostigmine and acetylcholine simultaneously.

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Correspondence to Luther H. Wolff.

Additional information

Abridgment of thesis submitted to the Faculty of the Graduate School of the University of Minnesota in partial fulfillment of the requirements for the degree of M.S. in Surgery. Work done in the Division of Experimental Medicine, The Mayo Foundation, Rochester, Minn.

Fellow in Surgery, The Mayo Foundation.

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Wolff, L.H. The effect of certain parenterally administered drugs on the Colon of the Dog. American Journal of Digestive Diseases 6, 243 (1939). https://doi.org/10.1007/BF02997125

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Keywords

  • Acetylcholine
  • Ephedrine
  • Physostigmine
  • Intestinal Motility
  • Pituitary Extract