Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The level of ascorbic acid in the blood and urine of patients with peptic ulcer

  • 38 Accesses

  • 3 Citations

Summary And Conclusions

  1. 1.

    Evidence is presented to show that hospitalized patients on ulcer management have lower levels of ascorbic acid in the blood and urine than normal individuals or patients with functional digestive disorders.

  2. 2.

    Evidence suggesting that peptic ulcer patients require greater amount of ascorbic acid is demonstrated by the fact that daily medication of Vitamin patients with peptic ulcer appears to be 50 mg. four times a day.

  3. 4.

    There appears to be no clinical evidence that ascorbic acid in doses large enough to maintain the excretion at the normal level is of any value in the treatment of patients with peptic ulcer with or without hemorrhage.

  4. 5.

    It is suggested that the metabolism of Vitamin C is influenced by activity and that lower blood and urine values are found in patients resting in bed than in active individuals.

This is a preview of subscription content, log in to check access.


  1. 1.

    Ingalls and Warren:New Eng. J. Med., 217: 443, Sept. 9, 1937.

  2. 2.

    Harris et al:Lancet, 11: 1488, 1936.

  3. 3.

    Nisenson and Cohen:Am. J. M. Se., 194: 63–70, July, 1937.

  4. 4.

    Rivers and Orison:Proc. Staff Meet. Mayo Clinic, June 19, 1937.

  5. 5.

    Finkle:J. Clin. Investigation, 16: 587–593, July, 1937.

  6. 6.

    Faulkner and Taylor:J. Clin. Investigation, 17: 69–75, Jan., 1938.

  7. 7.

    Wright et al:Arch. Int. Med., 60: 264–271, Aug., 1937.

  8. 8.

    Wilbur and Wilder:Arch. Int. Med., 59: 530–538, March, 1937.

  9. 9.

    Wilbur and Wilder:Arch. Int. Med., 61: 343–349, Feb., 1938.

  10. 10.

    Lazarus:Brit. M. J., 2: 1011–1015, Nov. 20, 1937.

Download references

Author information

Correspondence to Donald T. Chamberlin or H. J. Perkin.

Additional information

From the Department of Gastro-Enterology and the Research Foundation, Lahey Clinic, Boston, Mass.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chamberlin, D.T., Perkin, H.J. The level of ascorbic acid in the blood and urine of patients with peptic ulcer. American Journal of Digestive Diseases 5, 493–497 (1938). https://doi.org/10.1007/BF02997084

Download citation


  • Ascorbic Acid
  • Peptic Ulcer
  • Duodenal Ulcer
  • Exophthalmic Goiter
  • Orange Juice