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A Modification of the Hippuric Acid Liver Function Test

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Summary and conclusions

A modification of the hippuric acid liver function test is herein described. The drug is administered intravenously instead of orally as in the original method. Certain advantages of this modification are pointed out, such as — smaller amounts of the drug used, better control of the amount of the drug given, no interference with the procedure in cases where vomiting is a factor, reducing the time necessary for collecting specimens as well as volume of individual specimens. The latter facilitates the laboratory procedure considerably. A comparative study of both methods was made on twenty-five patients, the close parallelism between the results obtained is indicated in the accompanying table. Using the new modification, a hippuric acid excretion (in terms of benzoic acid) of between 0.8 grams and 1.3 grams is found in patients with a normally functioning liver.

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    Quick, A. J.: The Synthesis of Hippuric Acid: A New Test of Liver Function.Am. J. Med. Sc., 185: 630–635, May, 1933.

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Correspondence to Emanuel W. Lipschutz.

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Lipschutz, E.W. A Modification of the Hippuric Acid Liver Function Test. American Journal of Digestive Diseases 6, 197–199 (1939). https://doi.org/10.1007/BF02997049

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  • Benzoic Acid
  • Hippuric Acid
  • Toxic Hepatitis
  • Sodium Benzoate
  • Menopausal Syndrome