Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

An experimental study of some chemical inhibitors of gastric acidity

  • 11 Accesses

  • 4 Citations

Summary

Transitory achlorhydria to histamine may be produced in dogs by exposure of the gastric mucosa to dilute solutions of mercuric or cupric salts; no effect was noted using salts of lead, manganese and zinc in much greater concentration. Quinone has a similar inhibiting action, while hydroquinone and resorcinol have no effect in 100 times as great concentration. Brilliant green and crystal violet stain the gastric mucosa and inhibit acid secretion.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Atkinson, A. J. and Ivy, A. C.: Further Attempts to Produce Achlorhydria.Am. J. Digest. Dis., 5:30–35, March, 1938.

  2. 2.

    Culmer, C. U., Atkinson, A. J. and Ivy, A. C.: Hydrogen Peroxide as a Depressant of Gastric Acidity.Am. J. Digest. Dis. and Nutrit., 4:219–223, June, 1937.

  3. 3.

    Mathews, A. P.: Physiological Chemistry, Ed. 3. New York, Wm. Wood and Company, p. 375, 1920.

  4. 4.

    Rigoni, M.: Ricerche sull’ureasi; l’ureasi mucosa gastrica dell’vomo e degli animali.Arch. di. sc. biol., 15:37–46, July, 1930.

  5. 5.

    Martin, Lay: Urease in Gastric Juice. Studies Demonstrating its Action and a Theoretical Consideration of the Method of Gastric Juice, Hydrochloric Acid Formation and Secretion.Tr. Am. Gastro-Enterol. A., pp. 3–21, 1932.

  6. 6.

    Luck, J. M. and Seth, T. N.: Gastric Urease.Biochem. J., 18:1227–1231, 1924.

  7. 7.

    Hellerman, L., Perkins, M. E. and Clark, W. M.: Urease Activity as Influenced by Oxidation and Reduction.Proc. Nat. Acad. Sc., 19:855–860, 1933.

  8. 8.

    Schmidt, E. G.: The Inactivation of Disease.J. Biol. Chem., 78:53–61, June, 1928.

  9. 9.

    Quastel, J. H.: The Action of Polyhydric Phenols on Urease; the Influence of Thiol Compounds.Biochem. J. (pt. II) 27:1116–1122, 1933.

  10. 10.

    Quastel, J. H.: The Action of Dyestuffs on Enzymes. III. Urease.Biochem. J. (pt. II) 26:1685–1696, 1932.

  11. 11.

    Hellerman, Leslie: Reversible Inactivations of Certain Hydrolytic Enzymes.Physiol. Rev., 17:454–484, July, 1937.

Download references

Author information

Correspondence to Frank C. Mann.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Mann, F.D., Mann, F.C. An experimental study of some chemical inhibitors of gastric acidity. American Journal of Digestive Diseases 6, 322–325 (1939). https://doi.org/10.1007/BF02996493

Download citation

Keywords

  • Quinone
  • Gastric Mucosa
  • Hydroquinone
  • Resorcinol
  • Crystal Violet