Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Study of trace elements (copper & zinc) in oral submucous fibrosis

  • 12 Accesses

Abstract

A study of serum levels of trace elements like copper and zinc in oral submucous fibrosis (O.S.M.F.) reveals that the mean serum copper level rises by 24.60 ug/100 ml (p<0.001) as compared to controls. The mean serum zinc level did not show any significant alteration. The copperzinc ratio also shows a rise of 0.28 (p<0.05). The maximum rise of mean serum copper level is observed in stage I of oral submucous fibrosis. This study may be helpful as an additional diagnostic tool for oral submucous fibrosis and may also reveal some clues about the advancement of disease. The mean rise in serum copper level is less in oral submucous fibrosis than in malignant lesions. This, though a lesser rise but a definite and constant one, may favour the possibility of oral submucous fibrosis being a pre-malignant lesion, as thought earlier by Paymaster (1956).

This is a preview of subscription content, log in to check access.

Bibliography

  1. 1.

    Davies, I.J.T., Musa, M.N., Dormandy, T.L. (1968): Measurement of plasma zinc in malignant disease.Journal of Clinical Pathology,21 : 363–365.

  2. 2.

    Dejorge, F.B., Paiva, L., Mion, P. and Da Nova, R. (1966): Biochemical studies on serum copper, copper oxidase, magnesium sulphur, calcium and phosphorus in cancer of larynx.Acta Otolaryngology,61 : 454–458.

  3. 3.

    Desa, J.U. (1957): Submucous fibrosis of cheeks and palate.Annals of Otology, Rhinology and Laryngology,66 : 1143.

  4. 4.

    Fuwa, K., Puldio, P., Mckay, R. and and Vallee, B.L. (1964): Determination of zinc in biological material by Atomic Absorption Spectrophotometry,Annals of Chemistry.36 : 2407–2411.

  5. 5.

    Habib, F.K., Dembinski, T.C. and Stitch, S.R. (1980): The zinc and copper content of blood leucocyte and plasma from patients with benign and malignant prostates.Clinica Chemica Acta,104 : 329–335.

  6. 6.

    Joshi, S.G. (1953): Submucous fibrosis of the palate and pillars,Indian Journal of Otolaryngology,4 : 1.

  7. 7.

    Parikh, V. and Sharma, V.P. (1979): Diagnostic value of trace elements (copper and zinc) on various malignancies,Indian Journal of Surgery,141 : 625.

  8. 8.

    Paymaster, J.C. (1956): Cancer of Buccal mucosa, A clinical study of 650 cases in Indian patients.Cancer,9 : 431.

  9. 9.

    Pindborg, J.J. (1965): Frequency of oral sbmucous fibrosis in North India,Bulletine of the world health organization,32 : 748.

  10. 10.

    Pindborg, J.J. and Sirsat, S.M. (1966): Oral submucous fibrosis,Oral surgery, oral medicine and oral Pathology,22 : 764.

  11. 11.

    Rajput, V.S., Gupta, S.N., Sur, K.N., Pandey, R.P. and Singh, S. (1979): A evaluation of serum copper levels in diagnosis and prognosis of variout malignancies,Indian Journal of Surgery,41 : 515.

  12. 12.

    Rao, A.B.N. (1962): Idiopathic palatal fibrosis,British Journal of Surgery,50 : 23.

  13. 13.

    Schwartz, M.K. (1975): Role of trace elements in cancer.Cancer Reaearch,35 : 3481–33487.

  14. 14.

    Sirsat, S.M. and Khanolkar, V.R. (1962): Submucous fibrosis of the palate and pillars of fauces,Indian Journal of Medical Sciences,16 : 189.

Download references

Author information

Correspondence to D. D. Hemani.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gupta, R.P., Rai, K., Hemani, D.D. et al. Study of trace elements (copper & zinc) in oral submucous fibrosis. Indian J Otolaryngol 39, 104–106 (1987). https://doi.org/10.1007/BF02994903

Download citation

Keywords

  • Zinc
  • Zinc Level
  • Serum Copper
  • Serum Zinc Level
  • Oral Submucous Fibrosis