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Measurements of total body calcium by prompt-gamma neutron activation abalysis using a252Cf source

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A clinical neutron activation instrument has been developed for in vivo elemental analysis. Utilizing the prompt-capture gamma ray technique, simultaneous total body (TB) measurements of primarily Ca, but also Cl, N, C, and H are routinely performed. This paper describes a technique for the measurement of TBCa (g) that relies on the use of TBCl as an internal standard. The method has been tested with four anthropomorphic phantoms covering a range of body habitus. The mean discrepancy between the measured and known Ca contents was 3.6%. The technique has been applied to two patient groups, and encouraging results were obtained.

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  1. 1.

    S. H Cohn,Atom. Energy Rev. 18, 599 (1980).

  2. 2.

    D. R. Chettle and J. H. Fremlin,Phys. Med. Biol. 29, 1011 (1984).

  3. 3.

    R. G. Zamenhof, O. L. Deutsch, and B. W. Murray,Med. Phys. 6, 170 (1979).

  4. 4.

    W. D. Morgan, S. J. S. Ryde, J. Dutton, C. J. Evans, and A. Sivyer,Proc. Vth Int. Conf. on Nucl. Meths. In Environ. and Energy Res , J. R. Vogt. ed., US DOE Conf-840408, 1984, pp.751–758.

  5. 5.

    W. D. Morgan, D. Vartsky, K. J. Ellis and S. H. Cohn,Phys. Med. Biol. 26, 413 (1981).

  6. 6.

    S. J. S. Ryde, W. D. Morgan, S. Cobbold, A. Sivyer, J. Dutton, C. J. Evans, J. E. Compston, and R. Motley,Osteoporosis and Bone Mineral Measurement (IPSM4), E. F. J. Ring, W. D. Evans and A. S. Dixon, eds. IPSM, York, UK, 1989, pp. 105–115.

  7. 7.

    S. J. S. Ryde,Ph D. Thesis, University of Wales 1988.

  8. 8.

    S. J. S. Ryde, W. D. Morgan, A. Sivyer, C. J. Evans, and J. Dutton,Phys. Med. Biol. 32, 1257 (1987).

  9. 9.

    D. Vartsky, N. W. Prestwich, B. J. Thomas, J. T. Dabek, D. R. Chettle, J. H. Fremlin, and K. Stammers,J. Radioanal. Chem. 48, 243 (1979).

  10. 10.

    S. Yasumura, S. H. Cohn, and K. J. Ellis,Am. J. Physiol. 244, R36 (1983).

  11. 11.

    D. K. Bewley,Phys. Med. Biol. 33, 805 (1988).

  12. 12.

    C. B. Oxby and K. Brooks,Phys. Med. Biol. 24, 440 (1979).

  13. 13.

    K. J. Ellis, private communication (1989).

  14. 14.

    J. E. Compston, W. D. Evans, E. O. Crawley, D. Judd, R. Motley, C. Evans, and J. Rhodes,In Vivo Body Composition Studies, K. J. Ellis, S. Yasumura, and W. D. Morgan, eds., IPSM, London, 1987, pp. 226–233.

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Correspondence to S. J. S. Ryde.

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Ryde, S.J.S., Morgan, W.D., Compston, J. et al. Measurements of total body calcium by prompt-gamma neutron activation abalysis using a252Cf source. Biol Trace Elem Res 26, 429–437 (1990). https://doi.org/10.1007/BF02992698

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Index Entries

  • In vivo neutron activation analysis
  • Ca measurement
  • neutron activation analysis
  • body composition analysis
  • Ca, in vivo measurement of
  • 252Cf
  • prompt gamma ray neutron activation
  • total body calcium