Indian Journal of Otolaryngology

, Volume 31, Issue 1, pp 11–13 | Cite as

Regional cyclophosphamide chemotherapy in advanced carcinoma maxilla

  • Arun V. Jamkar
  • R. S. Kanchan
  • A. G. Rege
Original Articles


14 patients of advanced carcinoma maxilla who presented to the Medical College Hospital, Aurangabad, were treated by intra-arterial cyclophosphamide chemotherapy. Two dosage regime of 200 mg. per day and 500 mg. per day were used either continuously or intermittently. Regression of tumour was obtained in only two cases and regression in size of lymph nodes in another two cases. Subjective improvement in form of feeling of well-being was obtained in two cases. In the other eight cases there was no effect on tumour. Neurological complications experienced were hemiplegia in two cases and transient paresis in two cases.


Medical College Hospital Hemiplegia Intermittent Infusion Superficial Temporal Artery Superior Thyroid Artery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bierman, H. R., Byron, R. L. Jr., Miller, S. R. and Shimkin, M. B. (1950), Effect of intra-arterial administration of Nitrogen-Mustard.American Journal of Medicine,8: 535.PubMedCrossRefGoogle Scholar
  2. 2.
    Calabresi, and Park (1970). In Pharmacological Basis of Therapeutics, Goodman, L. S. and Gillman, Alfred Ed. 4th edition, London, Macmillan Co., page 1356.Google Scholar
  3. 3.
    Donegan, W. L. (1975). Regional perfusion chemotherapy for Cancer of Head and Neck.Surgery Annual Nyhus, L. M. Ed., page 137.Google Scholar
  4. 4.
    Epsinar, H. J. (1968). The Rational and Development of a method of regional chemotherapy in Cancer of Head and Neck.British Journal of Plastic Surgery,21: 94.CrossRefGoogle Scholar
  5. 5.
    Harrison, D. F. N. (1965). Clinical experience of chemotherapy.Archives of Otolaryngology,81: 175.PubMedGoogle Scholar
  6. 6.
    Jesse, R. H., Villareal, R., Ruffino, C. and Kikey, R. C. (1964). Intra-arterial infusion of Head and Neck Cancers.Archives Of Surgery,88: 618.PubMedGoogle Scholar
  7. 7.
    Klopp, C. T., Alford, T. C., Bataman, J., Berry, G. M. and Winship, T. (1962). Fractionated intra-arterial Cancer chemotherapy with Bis-amino hydrochloride, as preliminary report.Annals Of Surgery,132: 811.CrossRefGoogle Scholar
  8. 8.
    Nervi, C., Areageli, G. and Casale, C. (1977). Reappraisal of Chemotherapy.Cancer,26: 577.CrossRefGoogle Scholar
  9. 9.
    Oberfield, R. A., Cady, B. and Booth, J. C. (1973). Regional arterial chemotherapy for advanced carcinoma of Head and Neck, 10 years review.Cancer,32: 82.PubMedCrossRefGoogle Scholar
  10. 10.
    Satoskar, Kale and Bhandarkar (1973). Pharmachology and Pharmacotherapeutics, Poona., Popular Prakashan, page 593.Google Scholar

Copyright information

© Association of Otolaryngologists of India 1979

Authors and Affiliations

  • Arun V. Jamkar
    • 1
  • R. S. Kanchan
    • 1
  • A. G. Rege
    • 1
  1. 1.Medical CollegeAurangabad

Personalised recommendations