The changes in propionate metabolism that accompany cobalt deficiency in sheep are described. Two groups of sheep, fed either a cobalt sufficient or deficient diet, were given an iv propionate load at intervals during a 14 w experiment. There was a tendency towards increased propionate half-life as the animals became cobalt deficient. However, significant changes in the area under the plasma methylmalonic acid-time curve occurred very early, indicating significant impairment of propionate metabolism. Despite this, the area under the plasma glucose-time curve was unaffected by cobalt deficiency, suggesting that the impairment of propionate metabolism, although significant, is not extensive.
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Kennedy, D.G., O'Harte, F.P.M., Blanchflower, W.J. et al. Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep. Biol Trace Elem Res 28, 233–241 (1991). https://doi.org/10.1007/BF02990470
- vitamin B12
- methylmalonic acid