Springer Nature is making SARS-CoV-2 and COVID-19 research free View research | View latest news | Sign up for updates

Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep

  • 51 Accesses

  • 10 Citations

Abstract

The changes in propionate metabolism that accompany cobalt deficiency in sheep are described. Two groups of sheep, fed either a cobalt sufficient or deficient diet, were given an iv propionate load at intervals during a 14 w experiment. There was a tendency towards increased propionate half-life as the animals became cobalt deficient. However, significant changes in the area under the plasma methylmalonic acid-time curve occurred very early, indicating significant impairment of propionate metabolism. Despite this, the area under the plasma glucose-time curve was unaffected by cobalt deficiency, suggesting that the impairment of propionate metabolism, although significant, is not extensive.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    H. R. Marston, S. H. Allen, and R. M. Smith,Nature 190, 1085, (1961).

  2. 2.

    E. N. Bergman, W. E. Roe, and K. Kon,Am. J. Physiol,211, 793, (1966).

  3. 3.

    J. P. Peters, and J. M. Elliot,J. Nutr,114, 660, (1984).

  4. 4.

    D. G. Kennedy, A. Cannavan, A. Molloy, F. P. M. O'Harte, S. M. Taylor, S. Kennedy, and W. J. Blanchflower,Br. J. Nutr. 64, 721, (1990).

  5. 5.

    A. MacPherson, and F. E. Moon,Trace Elements in Man and Animals 3, pp. 624–627. Commonwealth Agricultural Bureau, UK, (1974).

  6. 6.

    A. MacPherson, F. E. Moon, and R. C. Voss,Br. Vet. J. 132, 294, (1976).

  7. 7.

    R. J. Kovachy, S. D. Copley, and R. H. Allen,J. Biol. Chem. 258, 11415, (1983).

  8. 8.

    C. H. McMurray, D. A. Rice, M. McLoughlin, and W. J. Blanchflower,Trace Elements in Man and Animals 5, pp. 603–608. Commonwealth Agricultural Bureau, UK (1985).

  9. 9.

    D. A. Rice, M. McLoughlin, W. J. Blanchflower, E. A. Goodall, and C. H. McMurray,Vet. Rec. 121, 472, 473, (1987).

  10. 10.

    D. A. Rice, M. McLoughlin, W. J. Blanchflower, C. H. McMurray, and E. A. Goodall,Biol. Trace Element Res. 22, 153–164, (1989)

  11. 11.

    F. P. M. O'Harte, D. G. Kennedy, W. J. Blanchflower, and D. A. Rice,Br. J. Nutr. 62, 729–738 (1989).

  12. 12.

    D. G. Kennedy, F. P. M. O'Harte, W. J. Blanchflower, and D. A. Rice,Vet. Res. Commun. 14, 255, (1990).

  13. 13.

    C. H. McMurray, W. J. Blanchflower, D. A. Rice, and M. F. McLoughlin,Chromatog. 378, 201–207, (1986).

  14. 14.

    C. Remesy, and C. Demigne,Biochem. J. 141, 85, (1974).

  15. 15.

    F. P. M. O'Harte, PhD Thesis, The Queens University of Belfast, (1989).

  16. 16.

    M. Somers,Aust. J. Exp. Biol. Med. Sci. 47, 219, (1969).

  17. 17.

    Y. Grohn, M. L. Buss, and L. A. Lindbery,Am. J. Vet. Res. 46, 952, (1985).

  18. 18.

    J. Price,Proc. Nutr. Soc. 49, 150A, (1990).

Download references

Author information

Correspondence to D. Glenn Kennedy.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kennedy, D.G., O'Harte, F.P.M., Blanchflower, W.J. et al. Sequential changes in propionate metabolism during the development of cobalt/vitamin B12 deficiency in sheep. Biol Trace Elem Res 28, 233–241 (1991). https://doi.org/10.1007/BF02990470

Download citation

Index Entries

  • Cobalt
  • vitamin B12
  • sheep
  • propionate
  • glucose
  • methylmalonic acid