Retention, dynamics of75Se and65Zn distribution, and elimination were studied in rats after separate or joint single doses of these metals.
White female Wistar rats were divided into four groups (fifteen rats each). Group I received Na2 75SeO3 (0.1 mg Se/kg i.g.), group II received Na2 75SeO3+ZnCl2 (5 mg Zn/kg s.c.), group III received65ZnCl2, and group IV received65ZnCl2+Na2SeO3.
The zinc and selenium contents in the tissues were estimated during 120 h after administration; excretion in urine and feces of animals was determined throughout the experiment.
Combined administration of zinc and selenium resulted in an enhanced selenium retention in the brain, spleen, kidneys, blood, lungs, and heart. A selenium-induced increase in the concentration of zinc was noted in the bowels, blood, liver, kidneys, spleen, brain, and lungs.
The effects of the zinc/selenium interaction were visible especially in the lowered level of excretion of these elements. Zinc induced a decrease in the excretion of selenium in urine, with no concomitant changes in the excretion in feces. However, a visible decrease in the excretion of zinc in the feces was observed in the presence of selenium.
The present results indicate an occurrence of clear-cut interaction effects between zinc and selenium administered simultaneously in the rat.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
C. P. Downes, C. A. Mc Auliffe, and M. R. C. Winter, inInorganic Perspectives in Biology and Medicine, Elsevier North-Holland Biomedical Press, 1979, pp. 241–270.
M. T. Lo and E. Sandi,J. Environ. Pathol. Toxicol. 4, 193 (1980).
L. Magos and M. Webb,CRC Critical Reviews in Toxicology 8, 1 (1980).
E. Komsta-Szumska and J. Chmielnicka,Clin. Toxicol. 18, 1327 (1981).
J. Chmielnicka, E. M. Bem, and P. Kaszubski,Environ. Res. 31, 266 (1983).
J. Chmielnicka, E. M. Bem, and P. Kaszubski,Environ. Res. 31, 273 (1983).
E. A. Brzeźnicka and J. Chmielnicka,Environ. Health Perspect. 39, 131 (1981).
E. A. Brzeźnicka and J. Chmielnicka,Environ. Health Perspect. 60, 411 (1985).
E. A. Brzeźnicka and J. Chmielnicka,Environ. Health Perspect. 60, 423 (1985).
G. N. Schrauzer, D. A. White, and C. J. Schneider,Bioinorg. Chem. 6, 265 (1976).
N. Imura and A. Naganuma,Nutrition Research, Suppl. I, pp. 499–507.
V. Eybl, J. Sykora, and F. Mertl. Metabolism of trace elements related to human diseases.Abstracts P-42 Nordic Symposium. June, 10–13, 1985.
P. L. Admodt, W. F. Rumble, G. S. Johnson, D. Foster, and J. Henkin,Am. J. Clin. Nutr. 32, 559 (1979).
A. S, Prasad,Ann. Rev. Pharmacol. Toxicol. 393 (1979).
P. Kristensen and J. C. Hansen,Toxicology 12, 101 (1979).
P. Kristensen and J. C. Hansen,Toxicology 16, 39 (1980).
B. Bopp, R. C. Sonders, and J. W. Kesterson,Drug Metabol. Rev. 13, 271 (1982).
E. Komsta-Szumska and J. Chmielnicka,Arch. Toxicol. 38, 217 (1977).
J. Chmielnicka, E. M. Bem, E. A. Brzeźnicka, and M. Kasperek,Environ. Res. 37, 419 (1985).
J. Chmielnicka, E. Komsta-Szumska, and G. Zaręba,Arch. Toxicol. 53, 165 (1983).
S. Y. Chen, P. J. Collip, and J. M. Heo,Biol. Trace Element Res. 7, 169 (1985).
J. Chmielnicka, E. A. Brzeźnicka, and A. Śniady,Arch. Toxicol. 59, 16 (1986).
M. P. Waalkes and C. D. Klassen,Fundam. Appl. Toxicol. 5, 473 (1985).
About this article
Cite this article
Chmielnicka, J., Zaręba, G., Witasik, M. et al. Zinc-selenium interaction in the rat. Biol Trace Elem Res 15, 267 (1988). https://doi.org/10.1007/BF02990143
- Zinc, administered to rats, distribution and elimination of
- selenium, administered to rats, distribution and elimination of