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Production of prostaglandin e by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue

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Abstract

The production of prostaglandin Eex vivo was studied in samples of 31 squamous cell carcinomas of the head and neck (SCCHN) and 12 adenocarcinomas of gastrointestinal tract (ACGI). As a control, the PGE production was measured in 22 samples of noninvolved mucosa in patients with SCCHN and 12 samples of gastrointestinal mucosas. The mean PGE production by SCCHN was significantly higher than in normal mucosa. Furthermore, the PGE production by tumors which recurred or spread to regional lymph node within 18 months after surgery was higher than in tumors which did not recur within that interval. Also, production of PGE by noninvolved mucosa was significantly higher in patients in which tumor recurred after surgery than in patients which were tumor free. On the other hand, the mean production of PGE by ACGI was not different from that of normal mucosa. These data show that determination of PGE production might have prognostic significance in SCCHN.

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References

  1. 1.

    Goodwin J S, Ceuppens J L: PRostaglandis, cellular immunity and cancer.Prostaglandins Leukotriens Cancer 4, 1 (1985).

  2. 2.

    Bennett A, Charlier E M, McDonald A M, Simpson J S, Stamford I F, Zebro T: Prostaglandins and breast cancer.Lancet ii, 624, (1977).

  3. 3.

    Bishop H, Haynes J, Evans D, Elston C, Johnson J, Blarney V: Radioimmunoassay (RIA) of prostaglandin E2 (PGE2) in primary breast cancer and its relationship to histologic grade.Clin Oncol 6, 380 (1980).

  4. 4.

    Rolland P H, Martin P M, Jacquemier J, Rolland A M, Toga M: Prostaglandin in human breast cancer. Evidence suggesting that an elevated prostaglandin production is a marker of high metastatic potential for neoplastic cells.J Natl Cancer Inst 64, 1061 (1980).

  5. 5.

    Vanderveen E E, Grekin R C, Swanson N A, Kragballe K: Arachidonic acid metabolites in cutaneous carcinoma.Arch Dermatol 122, 407 (1986).

  6. 6.

    Hendrick A M, Mitchell M D, Harris A L: Plasma prostaglandins in lung cancer.Eur J Cancer Clin Oncol 24, 1069 (1988).

  7. 7.

    Karmali R A, Welt S, Thaler H T, Lefevre F: Prostaglandins in breast cancer:relationship to disease stage and hormone status.Br J Cancer 48, 689 (1983).

  8. 8.

    Malachi T, Chaimoff C, Feller N, Halbrecht I: PGE2 and cyclic AMP in tumor and plasma of breast cancer patients.J Cancer Res Clin Oncol 102, 71 (1981).

  9. 9.

    Bennett A, Carrol M A, Melhuish P B, Stamford I F:Treatment of mouse carcinoma in vivo with a prostaglandin E2 analogue and indomethacin.Br J Cancer 2, 245 (1985).

  10. 10.

    Fulton AM: In vitro effects of indomethacin on the growth of murine mammary tumors.Cancer Res 44, 2416 (1984).

  11. 11.

    Hubbard N E, Chapkin R S, Erickson K L: Inhibition of growth and linoleate-enhanced metastases of a transplant-able mouse mammary tumor by indomethacin.Cancer Res 43, 111 (1988).

  12. 12.

    Lynch N R, Casatles M, Astonin M, Salomon J C:Mechanism of inhibition of tumor growth by aspirin and indomethacin.Br J Cancer 38, 503 (1978).

  13. 13.

    Santoro M G, Philpott G W, Jaffe B M: Inhibition of tumor growth in vivo and in vitro by prostaglandin E.Nature 263, 777 (1976).

  14. 14.

    Santoro M G, Jaffe B M: Inhibition of Friend erythroleukaemia cell tumors in vivo by a synthetic analogue of prostaglandin E2.Br J Cancer 39, 408 (1979).

  15. 15.

    Hubbard W C, Alley C, McLemore T L, Boyd MR:Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate and ovarian tumors.Cancer Res 48, 4770 (1988).

  16. 16.

    Berlinger N T: Deficient immunity in head and neck cancer due to excessive monocyte production of prostaglandins.Laryngoscope 94, 1407 (1984).

  17. 17.

    Bennett A, Carter L, Stamford I F, Tanner N S B:Prostaglandin-like material extracted from squamous carcinomas of the head and neck.BrJ Cancer 41, 204 (1980).

  18. 18.

    Jung T T K, Berlinger N T, Juhn K: Prostaglandins in squamous cell carcinoma of the head and neck:a preliminary study.Laryngoscope 95, 307 (1985).

  19. 19.

    Johnson J T, Rabin B S, Wagner R L: Prostaglandin E2 of the upper aerodigestive tract.Ann Otol Rinol Laryngol 96, 213 (1987).

  20. 20.

    Klapan I, Snyderman C H, Heo D S, Johnson J T, Whiteside T L: Prostaglandin production and immunosuppression by squamous cell carcinomas of the head and neck.Arch Otolaryngol Head Neck Surg (submitted) (1991).

  21. 21.

    Snyderman C H, Klapan I, Heo D S, Wagner R, Johnson J T, Whiteside T L: In vitro production of prostaglandin E2 by squamous cell carcinoma of the head and neck.Arch Otolaryngol Head Neck Surg (submitted) (1991).

  22. 22.

    Pinto S, Gallo O, Dilaghi M, Gallina E, Giannini A, Coppo M, Pannincia R, Prisco D, Abbate R: Prostaglandins in squamous cell carcinoma of the larynx:tumor and peritumor synthesis.Prostaglandins Leukotriens Essential Fatty Acids 39, 53 (1990).

  23. 23.

    Botha J H, Robinson K M, Ramchurren N, Reddi K, Mormon R J: Human oesophageal carcinoma cell lines: prostaglandin production, biological properties and behaviour in nude mice.JNCI 76, 1053 (1986).

  24. 24.

    El Atar T M A, Lin H S, Vanderhoek J Y: Biosynthesis of prostaglandins and hydroxy fatty acids in primary squamous carcinomas of head and neck in humans.Cancer Letters 27, 255 (1985).

  25. 25.

    Honn K, Cicone B, Skoff A: Prostacycline: A potent antimetastatic agent.Science 212, 1270 (1981).

  26. 26.

    Slotman G J: Plasma tromboxane A2 and prostacyclin concentration in squamous cell carcinoma of the head and neck.J Surg Oncol 38, 33 (1988).

  27. 27.

    Bennett A, Civier A, Hensby C N, Melhuish, Stamford I F: Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissue.Gut 28, 315 (1987).

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Correspondence to F. ČULO or I. Klapan or V. Katic or T. Kolak or B. Bakula.

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ČULO, F., Klapan, I., Katic, V. et al. Production of prostaglandin e by squamous carcinoma of the head and neck and adenocarcinoma of gastrointestinal tissue. Med Oncol. & Tumor Pharmacother. 9, 35–39 (1992). https://doi.org/10.1007/BF02989651

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Key Words

  • Head and neck cancer
  • Gastrointestinal cancer
  • PGE