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Cranial irradiation and cerebrospinal fluid levels of 6-mercaptopurine in children with acute leukemia

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Abstract

We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial irradiation in order to evaluate a possible change in blood-brain barrier permeability to orally administered 6-mercaptopurine. Considerable interpatient variability has been observed in both plasma and cerebrospinal fluid 6-mercaptopurine levels. No statistical differences in the 6-mercaptopurine cerebrospinal fluid levels under the three different conditions could be detected. Our data suggest that cranial irradiation does not significantly influence the cerebrospinal fluid levels.

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References

  1. 1.

    Riehm H, Gadner H, Henze G, Kornhuber B, Langermann H J, Muller-Weihrich S, Schellong G: Acute lymphoblastic leukemia: treatment results in three BFM studies (1970–1981), in Murphy S B, Gilbert J L (eds):Leukemia Research: Advances in Cell Biology and Treatment, pp. 251–263. Elsevier (1983).

  2. 2.

    Aur R J A, Simone J, Hustu H O, Walters T, Borella L, Pratt C, Pinkel D: Central nervous system therapy and combination chemotherapy of childhood ALL.Blood 37, 272 (1971).

  3. 3.

    Price R A, Jamieson P A: The central nervous system in childhood leukemia II. Subacute encephalopathy.Cancer 35 (2), 306 (1975).

  4. 4.

    Creutzig U, Ritter J, Riehm H, Langermann H J, Henze G, Kabish H, Niethammer D, Jurgens H, Stollman B, Lasson U, Kaufman U, Loffler H, Schellong G: Improved treatment results in childhood acute myelogeneous leukemia: a report from the German cooperative study AML BFM 78.Blood 65, 298 (1985).

  5. 5.

    Narang P R, Jeager R L, Chatterji D C: Quantification of 6-MP in biologic fluid using HPLC: a selective and novel procedure.J Chromat 230, 373 (1982).

  6. 6.

    Tidd D M, Peterson A P R: A biochemical mechanism for the delayed cytotoxic reaction of 6- mercaptopurine.Cancer Res 34, 738 (1974).

  7. 7.

    Griffin T W, Rasey J S, Bleyer W A: The effect of photon irradiation on blood brain barrier permeability to MTX in mice.Cancer 40 (3), 1109 (1977).

  8. 8.

    Clemente C D, Holst E A: Pathological changes in neurons neuroglia and blood brain barrier induced by X irradiation of the head of monkeys.AMA Arch Neurol Psychiat 71, 66 (1954).

  9. 9.

    Hayder S, Lafolie P, Bjork O, Ahstrom L, Perteson C: 6-Mercaptopurine in cerebrospinal fluid during oral maintenance therapy of children with acute lymphoblastic leukemia.Med Oncol tumor Pharma-cother 5 (3), 187 (1988).

  10. 10.

    Riccardi R, Balis F, Ferrara P, Poplack D G, Mastrangelo R: Influence of food intake on bioavail-ability of oral 6-MP in children with acute lymphoblastic leukemia.Pediat Hematol Oncol 3 (4), 319 (1986).

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Correspondence to Riccardo Riccardi or Anna Lasorella or Rosa Laura Tartaglia or Anna Riccardi or Tiziana Servidei or Renato Mastrangelo.

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Riccardi, R., Lasorella, A., Tartaglia, R.L. et al. Cranial irradiation and cerebrospinal fluid levels of 6-mercaptopurine in children with acute leukemia. Med. Oncol. & Tumor Pharmacother. 8, 95–98 (1991). https://doi.org/10.1007/BF02988860

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Key words

  • 6-Mercaptopurine
  • Cranial irradiation
  • Childhood leukemia