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The role of radionuclide lymphoscintigraphy in extremity lymphedema

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Abstract

The characteristics of lymphedema on radionuclide lymphoscintigraphy were studied, and the diagnostic value of radionuclide lymphoscintigraphy in lymphedema was evaluated. In this report radionuclide lymphoscintigraphy was performed in 110 cases of clinically suspected lymphedema. A retrospective study method was used to analyze the imaging results. The typical pattern of lymphedema on radionuclide lymphoscintigraphy was summarized. It was found that the characteristics of lymphedema on radionuclide lymphoscintigraphy were diverse. The most common pattern was increased radiotracer accumulation in the soft tissue and lymphatic webs. Surgery and infection dominated as the causes of lymphedema in this study. It was concluded that radionuclide lymphoscintigraphy is a useful noninvasive method for diagnosing lymphedema. It is easy to operate and provides reliable results.

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References

  1. 1.

    Tiwari A, Cheng KS, Button M, Myint F, Hamilton G. Differential diagnosis, investigation, and current treatment oflower limb lymphedema.Arch Surg 2003; 138: 152–161.

  2. 2.

    Szuba A, Shin WS, Strauss HW, Rockson S. The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema.J Nucl Med 2003; 44: 43–57.

  3. 3.

    Sherman A, Ter-Pogossian M. Lymph node concentration of radioactive colloidal gold following interstitial injection.Cancer 1953; 6: 1238–1240.

  4. 4.

    Nawaz K, Hamad MM, Sedek S, Awdeh M, Eklof B, Abdel-Dayem HM. Dynamic lymph flow imaging in lymphedema: Normal and abnormal patterns.Clin Nucl Med 1986; 11: 653–658.

  5. 5.

    Cambria RA, Gloviczki P, Naessens JM, Wahner HW. Noninvasi ve evaluation of the lymphatic system with lymphoscintigraphy: a prospective, semiquantitative analysis in 386 extremities.J Vas Surg 1993; 18: 773–782.

  6. 6.

    Schirger A. Lymphedema.Cardiovas Clin 1983; 13: 293–305.

  7. 7.

    Sage HH, Gozun BV. Lymphatic scintigrams: a method for studying the functional pattern of lymphatics and lymph nodes.Cancer 1958; 11: 200–203.

  8. 8.

    Weissleder H, Weissleder R. Lymphedema: evaluation of qualitative and quantative lymphoscintigraphy in 238 patients.Radiology 1988; 167: 729–735.

  9. 9.

    Henze E, Scheiben HR, Collins JD, Najafi A, Barrio JR, Bannett LR. Lymphoscintigraphy with Tc-99m-labeled dextran.J Nucl Med 1982; 23: 923–929.

  10. 10.

    Ohtake E, Asaga T, Inaba M. Sentinel lymphoscintigraphy in patients with breast cancer undergoing excision biopsy.Ann Nucl Med 2002; 19: 671–675.

  11. 11.

    Samuels LD. Lymphoscintigraphy.Lymphology 1987; 20: 4–9.

  12. 12.

    Nawaz MK, Hamad MM, Abdel-Dayem HM, Sadek S, Eklif BG. Tc-99m human serum albumin lymphoscintigraphy in lymphedema of the lower extremities.Clin Nucl Med 1990; 11: 794–799.

  13. 13.

    Weissleder H, Weissleder R. Interstitial lymphangiogra- phy: initial clinical experience with a dimeric nonionic contrast agent.Radiology 1989; 170: 371–374.

  14. 14.

    Doldi SB, Lattuada E, Zappa MA, Pieri G, Favara A, Micheletto G. Ultrasonography of extremity lymphedema.Lymphology 1992; 25: 129–133.

  15. 15.

    Mortel M, Cluzan R, Ghabbouns S, Pascot M, Alliot F, Lasry JL. Transaxial computer tomography of lower extremity lymphedema.Lymphology 1998; 31: 180–185.

  16. 16.

    Werner GT, Scheck R, Kaiserling E. Magnetic resonance imaging of peripheral lymphedema.Lymphology 1998; 31: 34–36.

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Correspondence to Zhibin Yuan or Libo hen or Quanyong Luo or Jifang Zhu or Hankui Lu or Ruisen Zhu.

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Yuan, Z., hen, L., Luo, Q. et al. The role of radionuclide lymphoscintigraphy in extremity lymphedema. Ann Nucl Med 20, 341–344 (2006). https://doi.org/10.1007/BF02987244

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Key words

  • radionuclide lymphoscintigraphy
  • lymphedema
  • 99mTc dextran