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Trace element metabolism in the chemically diabetic rat

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Abstract

It is well-established that the metabolism of essential trace metals is homeostatically controlled. However, the factors responsible for coordinating processes of absorption, excretion, and flux among and within tissues remain unknown. Using the streptozotocin-diabetic rat as a model, we have obtained information in support of the hypothesis that the relative amounts of insulin and glucagon in plasma have a marked influence on the metabolism of the micronutrients Zn, Cu, Mn, and Fe. We have also found that alterations in trace metal metabolism during periods of acute stress (increased plasma glucagon to insulin ratio) are necessary for biochemical adaptation to the physiological state. Finally, we suggest that changes in the tissue distribution of these trace metals during periods of chronic endocrine imbalance may contribute to the onset of secondary complications.

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Correspondence to Mark L. Failla.

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Failla, M.L. Trace element metabolism in the chemically diabetic rat. Biol Trace Elem Res 5, 275 (1983). https://doi.org/10.1007/BF02987213

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Index Entries

  • diabetes mellitus, and trace element metabolism
  • zinc, in the diabetic rat
  • copper, in the diabetic rat
  • manganese, in the diabetic rat
  • iron, in the diabetic rat
  • metallothionein, in the diabetic rat
  • trace metal absorption, in the diabetic rat
  • trace metal urinary excretion, in the diabetic rat
  • arginase, and trace element metabolism
  • nutritional immunity, and trace element metabolism
  • urinary excretion, of trace elements in the diabetic rat
  • excretion, of trace elements in the diabetic rat
  • immunity, and trace element metabolism
  • absorption, of trace elements in the diabetic rat