Therapy-related myelodysplastic syndrome and therapy-related acute myelocytic leukemia (AML) are now recognized as hematologic malignancies that occur a few years after chemotherapy for primary malignancy with alkylating agents or topoisomerase II inhibitors. The secondary leukemia is usually AML and sometimes is preceded by a myelodysplastic syndrome. Acute lymphoblastic leukemia (ALL) as a secondary leukemia is quite rare, and secondary T-cell ALL after AML is even rarer. We report a case of a 56-year-old woman who developed T-cell ALL after a 3-year remission of AML (M2). We thought that this case would be extremely valuable for studying the etiology and biological characteristics of T-cell ALL as a secondary leukemia after AML.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Pedersen-Bjergaard J, Philip P, Larsen SO, et al. Therapy-related myelodysplasia and acute myeloid leukemia: cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series.Leukemia. 1993;7:1975–1986.
Andersen MK, Christiansen DH, Jensen BA, Ernst P, Hauge G, Pedersen-Bjergaard J. Therapy-related acute lymphoblastic leukemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992.Br J Haematol. 2001;114: 539–543.
Zeidman A, Dayan DB, Mittelman M. Secondary myelodysplastic syndromes and acute leukemias.Haematologia (Budp). 1995;27: 23–28.
Pui CH, Relling MV. Topoisomerase II inhibitor-related acute myeloid leukaemia.Br J Haematol. 2000;109:13–23.
Leone G, Voso MT, Sica S, Morosetti R, Pagano L. Therapy related leukemias: susceptibility, prevention and treatment.Leuk Lymphoma. 2001;41:255–276.
Super HJ, McCabe NR,Thirman MJ, et al. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II.Blood. 1993;82:3705–3711.
Dawson L, Slater R, Hagemeijer A, Langerak W, Willemze R, Kluin-Nelemans JC. Secondary T-acute lymphoblastic leukaemia mimicking blast crisis in chronic myeloid leukaemia.Br J Haematol. 1999;106:104–106.
Levendoglu-Tugal O, Weiss R, Ozkaynak MF, et al. T-cell acute lymphoblastic leukemia after renal transplantation in childhood.J Pediatr Hematol Oncol. 1998;20:548–551.
Perotti D, Sozzi G, Ferrari A, et al. Cytogenetic and molecular characterization of T-cell acute lymphoblastic leukemia as a second tumor after anaplastic large-cell lymphoma in a boy.Haematologica. 1999;84:554–557.
Kaplinsky C, Frisch A, Cohen IJ, et al. T-cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma.Med Pediatr Oncol. 1992;20:229–231.
Liso V, Specchia G, Pannunzio A, Mestice A, Palumbo G, Biondi A. T-cell acute lymphoblastic leukemia occurring in a patient with acute promyelocytic leukemia.Haematologica. 1998;83:471–473.
Hwang LY, Baer RJ. The role of chromosome translocations in T cell acute leukemia.Curr Opin Immunol. 1995;7:659–664.
Suto Y, Sato Y, Smith SD, Rowley JD, Bohlander SK. A t(6;12) (q23;p13) results in the fusion of ETV6 to a novel gene, STL, in a B-cell ALL cell line.Genes Chromosomes Cancer. 1997;18:254–268.
Dastugue N, Duchayne E, Kuhlein E, et al. Acute basophilic leukaemia and translocation t(X;6)(p11;q23).Br J Haematol. 1997;98: 170–176.
About this article
Cite this article
Tsuboi, K., Komatsu, H., Miwa, H. et al. T-Cell Acute Lymphoblastic Leukemia as a Secondary Leukemia after a 3-Year Remission of Acute Myelocytic Leukemia. Int J Hematol 77, 518–521 (2003). https://doi.org/10.1007/BF02986622
- Secondary T-ALL
- Chromosome 6q23
- TCR β
- TCR γ