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T-Cell Acute Lymphoblastic Leukemia as a Secondary Leukemia after a 3-Year Remission of Acute Myelocytic Leukemia


Therapy-related myelodysplastic syndrome and therapy-related acute myelocytic leukemia (AML) are now recognized as hematologic malignancies that occur a few years after chemotherapy for primary malignancy with alkylating agents or topoisomerase II inhibitors. The secondary leukemia is usually AML and sometimes is preceded by a myelodysplastic syndrome. Acute lymphoblastic leukemia (ALL) as a secondary leukemia is quite rare, and secondary T-cell ALL after AML is even rarer. We report a case of a 56-year-old woman who developed T-cell ALL after a 3-year remission of AML (M2). We thought that this case would be extremely valuable for studying the etiology and biological characteristics of T-cell ALL as a secondary leukemia after AML.

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Correspondence to Kazuya Tsuboi or Hirokazu Komatsu or Hiroshi Miwa or Shinsuke Iida or Shougo Banno or Atsushi Wakita or Masakazu Nitta or Ryuzo Ueda.

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Tsuboi, K., Komatsu, H., Miwa, H. et al. T-Cell Acute Lymphoblastic Leukemia as a Secondary Leukemia after a 3-Year Remission of Acute Myelocytic Leukemia. Int J Hematol 77, 518–521 (2003).

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Key words

  • Secondary T-ALL
  • Chromosome 6q23
  • TCR β
  • gene
  • TCR γ
  • gene