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Determination of chemical warfare agents

Gas Chromatographic analysis of chlorovinylarsines (Lewisite) and their metabolites by derivatization with thiols (2nd communication)

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Abstract

Chlorovinylannes (Lewisites) were produced and handled during WW I and WW II as chemical warfare agents. Residues of these cwa and their metabolites are still present today and continue to contaminate soil and water.

A gas Chromatographic method for the detection and determination of chlorovinylarsines (Lewisites) and their metabolites is shown. Lewisite II and Lewisite III, but not Lewisite I and the metabolites of Lewisite I and Lewisite II can be detected and determined using GC/ECD. After derivatization with thiols, the sum of Lewisite I or Lewisite II and their metabolites are detected. With the proper selection of the thiol, matrix interferences can be eliminated because of the different retention times of the derivatives.

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References

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    Franke, S.; Koehler, K.F.; Zaddach, H. (1994): Chemie der Kampfstoffe. Munster

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    Haas, R. (1996): Blaukreuzkampfstoffe. Chemisches Verhalten und humantoxikologische Bedeutung von Diphenylarsinver-bindungen. 1. Chemische Reaktionen. Umweltmed Forsch Prax 1, 183–189

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    Haas, R.;Schmidt, T.C. (1997): Chemische Reaktionen von Phenylarsinverbindungen. 3. Reaktion von Phenyl-Arsen-Verbindungen mit Dithiolen. UWSF — Z. Umweltchem. Ökotox. 9, 183–184

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    Haas, R.;Krippendorf, A. (1997): Determination of Chemical Warfare Agents in Soil and Material Samples. Gas Chromatographic Analysis of Phenylarsenic Compounds (Sternutators) (1st Communication). ESPR — Environ. Sci. & Poll. Res. 4, 123–124

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    Haas, R.;Krippendorf, A.;Steinbach, K. (1998): Chemische Reaktionen von Chlorvinylarsinverbindungen (Lewisite). 1. Reaktion von 2,2′-Dichlordivinylarsinchlorid (Lewisit II) mit Alkoholen. UWSF — Z. Umweltchem. Ökotox. 10, 64–65

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    Haas, R.; Krippendorf, A. (1998): Chemische Reaktionen von Chlorvinylarsinverbindungen (Lewisite). 2. Reaktion von 2-Chlorvinylarsindichlorid (Lewisit I) mit Alkoholen. UWSF - Z. Umweltchem. Ökotox. in print

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Correspondence to Rainer Haas.

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Haas, R. Determination of chemical warfare agents. Environ. Sci. & Pollut. Res. 5, 2–3 (1998). https://doi.org/10.1007/BF02986365

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Keywords

  • Analysis
  • arsenic compounds
  • chemical warfare agents
  • chlorovinylarsines
  • cwa
  • derivatization
  • detection
  • determination
  • gas chromatography
  • Lewisite