Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Double-blind, placebo-controlled lithium treatment in chemotherapy induced aplasia for AML: Reduced antibiotic requirement


A double-blind placebo-controlled study on lithium (Li) therapy after chemotherapy-induced bone marrow aplasia was undertaken in 53 patients with acute myeloblastic leukemia (AML). No difference was observed between the two groups for the duration of aplasia, the number of units of platelets or RBC transfused, the complete remission rate or the disease free survival. However, a statistically significant reduction in the number of days of antibiotic therapy required was found in the treated group (10.55 ± 2.72 vs 12.73 ± 3.60,P < 0.05).

This is a preview of subscription content, log in to check access.


  1. 1.

    Mayfield D, Brown R G: The clinical laboratory and electroencephalographic effects of lithium.J Psychiatr Res 4, 207 (1966).

  2. 2.

    Risetto G, Gassano G: Variazioni del sangue pertifico nella intossicazione sperimentale de sali di litio.Riv. Patol Clin sper 7, 202 (1976).

  3. 3.

    Boogs D R, Joyce R A: The hematopoietic effects of lithium.Sem Hemat 20, 129 (1983).

  4. 4.

    Doukas M A, Niskanen E, Quesenberry P J: Effect of lithium on stem cell and stromal cell proliferationin vitro.Exp Hemat 14, 215 (1986).

  5. 5.

    Gupta R C, Robinson W A, Kurnick J E: Felty’s syndrome: effect of lithium on granulopoiesis.Am J Med 61, 29 (1976).

  6. 6.

    Joyce R A, Boggs D R, Chervenick P A, Lalezary P: Neutrophil kinetics in Felty’s syndrome.Am J Med 69, 695 (1980).

  7. 7.

    Barret A J, Griscelli C, Buriot D, Faille A: Lithium therapy in congenital neutropenia. Correlation between clinial response anin vitro studies.Pediatr Res 13, 429 (1979).

  8. 8.

    Charron D, Barrett A J, Faille A, Alby N, Schmit T, Degos L: Lithium in acute myeloid leukemia.Lancet 1, 1307 (1977).

  9. 9.

    Lyman G H, Williams C C, Preston D, Goldman A, Dinwoodie W R, Saba H, Hartmann R, Jensen R, Shykowsky L: Lithium carbonate in patients with small cell lung cancer receiving combination chemotherapy.Am J Med 70, 1222 (1981).

  10. 10.

    Stein R, Beaman C, Ali M, Hansen R, Jenkins D D, Jume’ An H G: Lithium carbonate attenuation of chemotherapy-induced neutropenia.New Engl J Med 297, 430 (1977).

  11. 11.

    Gallicchio V S: Lithium and hematopoietic toxicity. I. Recoveryin vivo of murine hematopoietic stem cell (CFU-S and CFU-Mix) after single-dose administration of cyclophosphamide.Exp Hemat 14, 395 (1986).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Collado, S., Charron, D. & Degos, L. Double-blind, placebo-controlled lithium treatment in chemotherapy induced aplasia for AML: Reduced antibiotic requirement. Med. Oncol. & Tumor Pharmacother. 5, 103–105 (1988). https://doi.org/10.1007/BF02985446

Download citation

Key words

  • Acute myeloblastic leukemia
  • Induced aplasia
  • Lithium
  • Bone marrow recovery