Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Tc-99m HMPAO brain SPECT in linear nevus sebaceous syndrome

  • 50 Accesses

  • 3 Citations


The authors present a case of linear nevus sebaceous syndrome (LNSS) with atrophy of bilateral frontotemporal areas of the brain, left cerebellum and hippocampus, and bilateral uncal dysplasia demonstrated by magnetic resonance imaging (MRI). Magnetic resonance angiography revealed bilateral internal carotid artery hypoplasia with absence of flow in the anterior and middle cerebral arteries. Tc-99m HMPAO brain SPECT demonstrated more areas of perfusion defects while MRI detected volume loss and gliosis in affected areas. Tc-99m HMPAO brain SPECT may be more useful for revealing absent or decreased perfusion areas of brain lesions than MRI in LNSS. Key words: linear nevus sebaceous syndrome, Tc-99m HMPAO brain SPECT, MRI, MR angiography.

This is a preview of subscription content, log in to check access.


  1. 1.

    Feuerstein RC, Mims LC. Linear nevus sebaceous with convulsions and mental retardation.Am J Dis Child 1962; 104:675–679.

  2. 2.

    Wilkes SR, Campbell RJ, Waller RR. Ocular malformation in association with ipsilateral facial nevus of Jadassohn.Am J Ophthalmol 1981; 92:344–352.

  3. 3.

    Duncan JL, Golabi M, Fredrick DR, Hoyt CS, Hwang DG, Kramer SG, et al. Complex limbal choristomas in linear nevus sebaceus syndrome.Ophthalmology 1998; 105:1459- 1465.

  4. 4.

    Alfonso I, Howard C, Lopez PF, Palomino JA, Gonzalez CE. Linear nevus sebaceous syndrome. A review.J Clin Neuroophthalmol 1987; 7:170–177.

  5. 5.

    Lambert HM, Sipperley JO, Shore JW, Dieckert JP, Evans R, Lowd DK. Linear nevus sebaceous syndrome.Ophthal- mology 1987; 94:278–282.

  6. 6.

    van de Warrenburg BP, van Gulik S, Renier WO, Lammens M, Doelman JC. The linear naevus sebaceus syndrome.Clin Neurol Neurosurg 1998; 100:126–132.

  7. 7.

    Levy-Reis I, Casasanto DJ, Gonzalez JB, Alsop DC, Glosser G, Maldjan JA, et al. Cortical reorganization in linear nevus sebaceous syndrome: a multimodality neuroimaging study.J Neuroimaging 2000; 10:225–228.

  8. 8.

    Wakabayashi C, Maehara T, Shimamura T, Cho N, Iizuka Y, Irimoto M, et al. Unilateral megalencephaly in linear nevus sebaceous syndrome: a neuroradiological case report.Radiat Med 1997; 15:65–69.

  9. 9.

    Laino L, Steensel MA, Innocenzi D, Camplone G. Familial occurrence of nevus sebaceus of Jadassohn: another case of paradominant inheritance?Eur J Dermatol 2001; 11:97–98.

  10. 10.

    Sato K, Kubota T, Kitai R. Linear sebaceous nevus syndrome (sebaceous nevus of Jadassohn) associated with abnormal neuronal migration and optic glioma: case report.Neurosurgery 1994; 35:318–320.

  11. 11.

    Grebe TA, Rimsza ME, Richter SF, Hansen RC, Hoyme HE. Further delineation of the epidermal nevus syndrome: two cases with new findings and literature review.Am J Med Genet 1993; 47:24–30.

  12. 12.

    Hager BC, Dyme IZ, Guertin SR, Tyler RJ, Tryciecky EW, Fratkin JD. Linear nevus sebaceous syndrome: megalen-cephaly and heterotopic gray matter.Pediatr Neurol 1991; 7:45–49.

  13. 13.

    Holden KR, Dekaban AS. Neurological involvement in nevus unis lateris and nevus linearis sebaceus.Neurology 1972; 22:879–887.

  14. 14.

    Sarwar M, Schafer ME. Brain malformations in linear nevus sebaceous syndrome: an MR study.J Comput Assist Tomogr 1988; 12:338–340.

  15. 15.

    Brodsky MC, Kincannon JM, Nelson-Adesokan P, Brown HH. Oculocerebral dysgenesis in the linear nevus sebaceous syndrome.Ophthalmology 1997; 104:497–503.

  16. 16.

    Okuda K, Matsui T, Kitaguchi M, Kihara M, Takahashi M. A case of linear sebaceous nevus syndrome associated with a cerebrovascular anomaly.Rinsho Shinkeigaku 1998; 38:471–173.

  17. 17.

    Brihaye J, Brihaye-van Geertruyden M, Retif J, Mercier AM. Late occurrence of additional ocular and intracranial pathologies in the linear naevus sebaceous (Feuerstein-Mims) syndrome.Acta Neurochir 1988; 92:132–137.

  18. 18.

    Podreka I, Suess E, Goldenberg G, Steiner M, Brucke T, Muller C, et al. Initial experience with technetium-99m HMPAO brain SPECT.J Nucl Med 1987; 28:1657–1666.

  19. 19.

    Nakano S, Kinoshita K, Jinnouchi S, Hoshi H, Watanabe K. Comparative study of regional cerebral blood flow images by SPECT using Xenon-131, iodine-123 IMP, and technetium-99m HMPAO.J Nucl Med 1989; 30:157–164.

Download references

Author information

Correspondence to Abdullah Özkiriş or Cem Evereklioglu or Mustafa Kula or Mehmet Somdaş or Kuddusi Erkiliç or Abdulhakim Coşkun.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Özkiriş, A., Evereklioglu, C., Kula, M. et al. Tc-99m HMPAO brain SPECT in linear nevus sebaceous syndrome. Ann Nucl Med 17, 703–706 (2003). https://doi.org/10.1007/BF02984979

Download citation


  • Single Photon Emission Compute Tomography
  • Middle Cerebral Artery
  • Magnetic Resonance Angiography
  • Brain Single Photon Emission Compute Tomography
  • Cerebral Blood Flow Image