The purpose of this study was to assess the quantitative accuracy of truncal FDG PET with a postinjection transmission scan.
Ten subjects with lung cancer were recruited for this study. Prior to the emission scan, a transmission scan was performed for 10 min. All subjects received 370 MBq of intravenous administration of FDG prior to a 60-min emission scan. Immediately following the emission scan, a postinjection transmission scan was performed. Emission data from 40 to 60 min postinjection were reconstructed with either pre- or postinjection transmission data and converted to a standardized uptake value (SUV) image. On each SUV image, 5 regions of interest were placed and regions of interest on the SUV image with a postinjection transmission scan (SUVpost) were plotted against those with preinjection transmission (SUVpre), and a regression line was generated. Using the slope and Y-intercept of the regression line, percent error of estimation of the SUV was calculated based on the following equation: % error = ISUVpre- SUVpostl x 100/SUVpre.
In the low SUV area (SUV = 1), the averaged percent error was 9.4 ± 12.0% (mean ± SD), whereas in the high SUV area (SUV = 10), the averaged percent error was 2.8 ± 3.1%. The least percent error was 1.8 ± 1:8% (SUV = 3.8) in this study.
In the study on truncal FDG PET with postinjection transmisson scan, the quantitative accuracy was preserved and the method is clinically available.
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Tsuchida, T., Sugimoto, K., Nishizawa, S. et al. Quantitative assessment of truncal FDG-PET examination with postinjection transmission scan —comparison with preinjection transmission scan—. Ann Nucl Med 18, 333–336 (2004). https://doi.org/10.1007/BF02984472
- postinjection transmission scan