Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Quantitative assessment of truncal FDG-PET examination with postinjection transmission scan —comparison with preinjection transmission scan—

Abstract

The purpose of this study was to assess the quantitative accuracy of truncal FDG PET with a postinjection transmission scan.

Methods

Ten subjects with lung cancer were recruited for this study. Prior to the emission scan, a transmission scan was performed for 10 min. All subjects received 370 MBq of intravenous administration of FDG prior to a 60-min emission scan. Immediately following the emission scan, a postinjection transmission scan was performed. Emission data from 40 to 60 min postinjection were reconstructed with either pre- or postinjection transmission data and converted to a standardized uptake value (SUV) image. On each SUV image, 5 regions of interest were placed and regions of interest on the SUV image with a postinjection transmission scan (SUVpost) were plotted against those with preinjection transmission (SUVpre), and a regression line was generated. Using the slope and Y-intercept of the regression line, percent error of estimation of the SUV was calculated based on the following equation: % error = ISUVpre- SUVpostl x 100/SUVpre.

Results

In the low SUV area (SUV = 1), the averaged percent error was 9.4 ± 12.0% (mean ± SD), whereas in the high SUV area (SUV = 10), the averaged percent error was 2.8 ± 3.1%. The least percent error was 1.8 ± 1:8% (SUV = 3.8) in this study.

Conclusion

In the study on truncal FDG PET with postinjection transmisson scan, the quantitative accuracy was preserved and the method is clinically available.

This is a preview of subscription content, log in to check access.

References

  1. 1.

    Hooper PK, Meikle SR, Eberl S, Fulham MJ. Validation of postinjection transmission measurements for attenuation correction in neurological FDG-PET studies.J Nucl Med 1996; 37:128–136.

  2. 2.

    Hamacher K, Coenen HH, Stocklin G. Efficient stereo-specific synthesis of non-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleo-philic substitution.J Nucl Med 1986; 27:235–238.

  3. 3.

    DeGrado TR, Turkington TG, Williams JJ, Stearns CW, Hoffman JM, Coleman RE. Performance characteristics of a whole-body PET scanner.J Nucl Med 1994; 35:1398–1406.

  4. 4.

    Carson RE, Daube-Witherspoon ME, Green MV. A method for postinjection PET transmission measurements with rotating source.J Nucl Med 1988; 29:1558–1567.

  5. 5.

    McCord ME, Bacharach SL, Bonow RO, Dilsizian V, Cuocolo A, Freedman N. Misalignment between PET transmission and emission scan: its effect on myocardial imaging.J Nucl Med 1992; 33:1209–1214.

  6. 6.

    Daube-Witherspoon ME, Carson RE, Green MV. Post-injection transmission attenuation measurements for PET.IEEE Trans Nucl Sci 1988; 35:757–761.

  7. 7.

    Thompson CJ, Ranger NT, Evans AC. Simultaneous transmission and emission scans in positron emission tomography.IEEE Trans Nucl Sci 1989; 36:1011–1016.

  8. 8.

    Ranger NT, Thompson CJ, Evans AC. The application of a masked orbiting transmission source for attenuation correction inPET. J Nucl Med 1989; 30:1056–1068.

  9. 9.

    Bettinardi V, Gilardi MC, Lucignani G, Landoni C, Rizzo G, Striano G, et al. A procedure for patient repositioning and compensation for misalignment between transmission and emission data in PET heart studies.J Nucl Med 1993; 34:137–142.

  10. 10.

    Oda K, Senda M, Toyama H, Ishii K, Amano M. Attenuation correction using postinjection transmission measurements for PET: the optimization of measurement conditions.KAKU IGAKU (Jpn J Nucl Med) 1994; 31:37–41.

Download references

Author information

Correspondence to Tatsuro Tsuchida or Katsuya Sugimoto or Sadahiko Nishizawa or Yoshiharu Yonekura or Harumi Itoh.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tsuchida, T., Sugimoto, K., Nishizawa, S. et al. Quantitative assessment of truncal FDG-PET examination with postinjection transmission scan —comparison with preinjection transmission scan—. Ann Nucl Med 18, 333–336 (2004). https://doi.org/10.1007/BF02984472

Download citation

Key words

  • FDG-PET
  • postinjection transmission scan
  • misregistration