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Mutagenic activity in Drosophila of two pyrrolizidine alkaloids

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Summary

The data on mutagenicity are shown in Table 1. Both fulvine and retrorsine show moderate activity, falling into Clark’s (1960) second category. Isatidine, the N-oxide of retrorsine is much less active than the base itself, a result which is consistent with those of Clark. Monocrotaline and fulvine induce translocations, but at a rate which is very low compared with the incidence of sex-linked recessive lethals (cf. Avanzi, 1961; Clark, 1963).

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References

  1. Avanzi, S. (1961). Chromosome breakage by pyrrolizidine alkaloids and modification of the effect by cysteine.Caryologia,14, 251–261.

  2. Brink, N. G. (1963). The effect of cyanide and azide on the mutagenic activity of the pyrrolizide alkaloid heliotrine inDrosophila melanogaster.Z. Vererb.-Lehre,94, 331–335.

  3. Clark, A. M. (1959). Mutagenic actvity of the alkaloid heliotrine inDrowphila.Nature,183, 731–732.

  4. Clark, A. M. (1960). The mutagenic activity of some pyrrolizidine alkaloids inDrosophila.Z. Vererb.-Lehre,91, 74–30.

  5. Clark, A. M. (1963), The brood pattern of sensitivity of theDrosophila test is to the mutagenic activity of heliotrine.Z. Vererb.-Lehre,94, 115–120.

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Author information

Correspondence to L. M. Cook.

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Cook, L.M., Holt, A.C.E. Mutagenic activity in Drosophila of two pyrrolizidine alkaloids. J Genet 59, 273–274 (1966). https://doi.org/10.1007/BF02984232

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Keywords

  • Alkaloid
  • Chromosome Breakage
  • Pyrrolizidine Alkaloid
  • Pyrrolizidine
  • Monocrotaline