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Mutagenic activity in Drosophila of two pyrrolizidine alkaloids

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The data on mutagenicity are shown in Table 1. Both fulvine and retrorsine show moderate activity, falling into Clark’s (1960) second category. Isatidine, the N-oxide of retrorsine is much less active than the base itself, a result which is consistent with those of Clark. Monocrotaline and fulvine induce translocations, but at a rate which is very low compared with the incidence of sex-linked recessive lethals (cf. Avanzi, 1961; Clark, 1963).

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Correspondence to L. M. Cook.

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Cook, L.M., Holt, A.C.E. Mutagenic activity in Drosophila of two pyrrolizidine alkaloids. J Genet 59, 273–274 (1966). https://doi.org/10.1007/BF02984232

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  • Alkaloid
  • Chromosome Breakage
  • Pyrrolizidine Alkaloid
  • Pyrrolizidine
  • Monocrotaline