The chromosome aberration t(7;11)(p15;p15) is uncommon but recurrent in leukemia. We experienced a case of acute leukemia with t(7;11)(p15;p15), the hematological appearance of which mimicked myeloid crisis in chronic myeloid leukemia (CML). This case showed splenomegaly, a decreased neutrophil alkaline phosphatase (NAP) score, increased vitamin B12 value, and cells at all stages of neutrophilic maturation in both bone marrow and peripheral blood. We initially had difficulty differentiating acute myeloid leukemia (AML) M2 with marked myeloid differentiation from myeloid crisis of Philadelphia chromosome (Ph)-negative CML. Immature myeloid cells in the peripheral blood disappeared and cytogenetic analysis indicated that marrow cells changed to the normal karyotype after remission induction therapy. Therefore, this case was thought not to be myeloid crisis but AML M2 subtype. TheNUP98/HOXA9 fusion transcript was detected by reverse transcription-polymerase chain reaction (RT-PCR) at exon A but not exon B ofNUP98.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
Tomiyasu T, Sasaki M, Kondo K, Okada M. Chromosome banding studies in 106 cases of chronic myelogenous leukemia.Jinrui Idengaku Zasshi. 1982;27:243–258.
Huang SY, Tang JL, Liang YJ,Wang CH, Chen YC,Tien HF. Clinical, haematological and molecular studies in patients with chromosome translocation t(7;11): a study of four Chinese patients in Taiwan.Br J Haematol. 1997;96:682–687.
Fujimura T, Ohyashiki K, Ohyashiki JH, et al.Two additional cases of acute myeloid leukemia with t(7;11)(p15;p15) having low neutrophil alkaline phosphatase scores.Cancer Genet Cytogenet. 1993;68:143–146.
Wong KF, So CC, Kwong YL. Chronic myelomonocytic leukemia with t(7;11)(p15;p15) andNUP98/HOXA9 fusion.Cancer Genet Cytogenet. 1999;115:70–72.
Kaneko Y, Maseki N, Takasaki N, Sakurai M, Kawai K, Sakurai M. Possible association of a new translocation, t(7;11)(p15;p15), with Ph1 chromosome-negative chronic myelogenous leukemia.Int J Cancer. 1985;36:657–659.
Takeda T, Ikebuchi K, Zaike Y, Mori M, Ohyashiki K, Ikeuchi T. Ph-negative chronic myelocytic leukemia with a complex translocation involving chromosomes 7 and 11.Cancer Genet Cytogenet. 1986;21:123–127.
Nishiyama M, Arai Y, Tsunematu Y, et al. 11p15 translocations involving theNUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome.Genes Chromosomes Cancer. 1999;26:215–220.
Hatano Y, Miura I, Nakamura T, Yamazaki Y, Takahashi N, Miura AB. Molecular heterogeneity of theNUP98/HOXA9 fusion transcript in myelodysplastic syndromes associated with t(7;11) (p15;p15).Br J Haematol. 1999;107:600–604.
Yamamoto K, Nakamura Y, Saito K, Furusawa S. Expression of theNUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11) (p15;p15).Br J Haematol. 2000;109:423–426.
Nakamura T, Largaespada DA, Lee MP, et al. Fusion of the nucle- oporin geneNUP98 toHOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukemia.Nature Genet. 1996;12:154–158.
Borrow J, Shearman AM, Stanton VP Jr, et al.The t(7;11)(p15;p15) translocation in acute myeloid leukemia fuses the genes for nucle- oporinNUP98 and class I homeoproteinHOXA 9.Nature Genet. 1996;12:159–167.
Kwong YL, Pang A. Low frequency of rearrangements of the homeobox geneHOXA9/t(7;11) in adult acute myeloid leukemia.Genes Chromosomes Cancer. 1999;25:70–74.
Arai Y, Hosoda F, Kobayashi H, et al. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in the nucleoporin gene,NUP98, with the putative RNA helicase gene,DDX10.Blood. 1997;89:3936–3944.
Fujino T, Suzuki A, Ito Y, et al. Single-translocation and double- chimeric transcripts: Detection ofNUP 98-HOXA9 in myeloid leukemias withHOXA11 orHOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15).Blood. 2002;99:1428–1433.
Sato Y, Abe S, Mise K, et al. Reciprocal translocation involving the short arms of chromosome 7 and 11, t(7p-;11p+), associated with myeloid leukemia with maturation.Blood. 1987;70:1654–1658.
Kwong YL, Chan TK. Translocation (7;11)(p15;p15) in acute myeloid leukemia M2: Association with trilineage myelodysplasia and giant dysplastic myeloid cells.Am J Hematol. 1994;47:62–64.
Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G.NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice.EMBO J. 2001;20: 350–361.
About this article
Cite this article
Kawakami, K., Miyanishi, S., Nishii, K. et al. A Case of Acute Myeloid Leukemia with t(7;11)(p15;p15) Mimicking Myeloid Crisis of Chronic Myelogenous Leukemia. Int J Hematol 76, 80–83 (2002). https://doi.org/10.1007/BF02982723