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T-Cell Type Acute Lymphoblastic Leukemia Following Cyclosporin A Therapy for Aplastic Anemia

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Cyclosporin A (CsA) is used to prevent rejection in transplantation and to treat autoimmune and hematologic diseases such as aplastic anemia. However, the tumor growth-promoting effect of CsA remains controversial. We report the case of a 24-year-old man who developed acute lymphoblastic leukemia of precursor-T-cell origin after 75 months of treatment with CsA for aplastic anemia. The surface antigen phenotype of his leukemic cells was CD2+, CD3+, CD5+, CD7+, CD4, CD8, CD10, CD20, CD34, CD41, and CD56. Southern blot analysis revealed a monoclonal rearrangement of T-cell receptor—J nongermline fragments inHindIII digestion.

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Correspondence to Yuko Hirose or Yasufumi Masaki or Kazumi Ebata or Jun Okada or Chang gi Kim or Noriyoshi Ogawa or Yuji Wano or Susumu Sugai.

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Hirose, Y., Masaki, Y., Ebata, K. et al. T-Cell Type Acute Lymphoblastic Leukemia Following Cyclosporin A Therapy for Aplastic Anemia. Int J Hematol 73, 226–229 (2001).

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Key words

  • T-ALL
  • Cyclosporin A
  • Aplastic anemia