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Vacillans, a neurological mutant in the house mouse linked with brown

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Summary

Vacillans is a gene that conditions a complex syndrome involving the muscular co-ordination, behaviour and reflexes, as well as some metabolic abnormality. The syndrome seems to a large extent independent of the residual genotype. It behaves as a recessive, and the symbolvc is proposed. Vacillans is linked withbrown, in the linkage group VIII, with a recombination value of 5.5 ±1.9% in females. Double heterozygotes of vacillans andshaker-1,agitans, ataxia andreeler show no interaction. The compoundvc/vc;sh-1/sh-1 is described.

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References

  1. Carter, T. C. &Falconer, D. S. (1951). Stocks for detecting linkage in the mouse, and the theory of their design.J. Genet. 50, 307–23.

  2. Ealconer, D. S. (1951). Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.).J. Genet. 50, 192–201.

  3. Grüneberg, H. (1952).The Genetics of the Mouse, 2nd ed., pp. xiv + 650. The Hague: Martinus Nijhoff.

  4. Hoecker, G., Martinez, A., Markovic, S. &Pizarro, O. (1954). Agitans, a new mutation in the house mouse (with neurological effects).J. Hered. 45, 10–14.

  5. Li, C. C. (1948).An Introduction to Population Genetics, pp. 321. Peiping: National Peking University Press.

  6. Lyon, M. F. (1951). Hereditary absence of otoliths in the house mouse.J. Physiol. 114, 410–18.

  7. Lyon, M. F. (1955). Ataxia: a new recessive mutant in the house mouse.J. Hered. 46, 77–80.

  8. Mouse News Letter (1953),8, 18–19.

  9. Russell, E. S. (1946). A quantitative histological study of the pigment found in the coat-color mutants of the house mouse. I. Variable attributes of the pigment granules.Genetics,31, 327–46.

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Correspondence to J. L. Sirlin.

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Sirlin, J.L. Vacillans, a neurological mutant in the house mouse linked with brown. J Genet 54, 42 (1956). https://doi.org/10.1007/BF02981700

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Keywords

  • House Mouse
  • Recombination Fraction
  • Double Heterozygote
  • Adult normM Mouse
  • Bridge Test