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A phenylpropanoid glycoside with antioxidant activity from picria tel-ferae

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Abstract

A phytochemical study on Picria tel-ferae resulted in the isolation of a phenylpropanoid glycoside (1), which was reported for the first time from this plant. The structure of compound 1 was identified as 1-O-3,4-(dihydroxyphenyl)-ethyl-β-D-apiofuranosyl-(1→4)-α-L-rharmnopyranosyl-(1→3)-4-O-caffeoyl-β-D-glucopyranoside on the basis of spectroscopic analyses. In addition, it was found that 1 exhibited a remarkable inhibitory effect on lipid peroxidation initiated by either a free radical [AAPH; 2,2′-azobis-(2-amidinopropane)dihydrochloride] or generated hydroxyl radical (Fe2+/ascorbate). These findings, together with those of previous studies, suggest that P. tel-ferae possesses abundant phenylpropanoid glycosides, and the plant might be used beneficially in the treatment of oxidative stress-related human diseases.

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Correspondence to Nguyen Duy Thuan or Do Thi Ha or Phuong Thien Thuong or Min Kyun Na or KiHwan Bae or Jong Pill Lee or Jeong-Hun Lee or Hyo-Won Seo or Byung-Sun Min or Jin-Cheol Kim.

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Thuan, N.D., Ha, D.T., Thuong, P.T. et al. A phenylpropanoid glycoside with antioxidant activity from picria tel-ferae. Arch Pharm Res 30, 1062–1066 (2007). https://doi.org/10.1007/BF02980238

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Key words

  • Picria tel-ferae
  • Scrophulariaceae
  • Phenylpropanoid glycoside
  • Antioxidant
  • Lipid peroxidation