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Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase


1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-unde-cenyl]-4(1H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.

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Correspondence to Xiang Hua Han or Seong Su Hong or Dongho Lee or Jung Joon Lee or Moon Soon Lee or Dong-Cheul Moon or Kun Han or Ki-Wan Oh or Myung Koo Lee or Jai Seup Ro or Bang Yeon Hwang.

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Han, X.H., Hong, S.S., Lee, D. et al. Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase. Arch Pharm Res 30, 397–401 (2007).

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Key words

  • Evodiae Fructus
  • Evodia rutaecarpa
  • Rutaceae
  • Monoamine oxidase inhibitor
  • Quinolone alkaloid