The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E2 (PGE2) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) productionin vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 μM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in micein vivo.
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Lee, S., Jung, S.H., Lee, Y.S. et al. Antiinflammatory activity of hyperin fromAcanthopanax chiisanensis roots. Arch Pharm Res 27, 628–632 (2004). https://doi.org/10.1007/BF02980162
- Acanthopanax chiisanensis
- Anti-inflammatory activity