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Methylation, an old/new player in the pathogenesis of neoplasia

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References

  1. 1.

    Esteller M, Baylin SB, Herman JG. Beyond the genetic lesions: gene inactivation by promoter hypermethylation in human cancer. Oncología 2000; 2: 61–66.

  2. 2.

    Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic neoplasia. Cancer Res 1988; 48: 1159–1161.

  3. 3.

    Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM, Dryja TP. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet 1991; 48: 880–888.

  4. 4.

    Herman JG, Latif F, Weng Y et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994; 91: 9700–9704.

  5. 5.

    Little M, Wainwright B. Methylation and p16: suppressing the suppressor. NatMed 1995; 1: 633–634.

  6. 6.

    Wainfan E, Poirier LA. Methyl groups in carcinogenesis: effects on DNA methylation and gene expression. Cancer Res 1992; 52: 2071–2077.

  7. 7.

    Kane MF, Loda M, Gaida GM et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repairdefective human tumor cell lines. Cancer Res 1997; 57: 808–811.

  8. 8.

    Esteller M, Hamilton SR, Burger PC, Baylin SB, Herman JG. Inactivation of DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999; 59: 793–797.

  9. 9.

    Meehan RR, Lewis JD, McKay S, Kleiner EL, Bird AP. Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs. Cell 1989; 58: 499–507.

  10. 10.

    Eden S, Hashimshony T, Keshet I, Cedar H, Thorne AW. DNA methylation models histone acetylation. Nature 1998; 394: 842.

  11. 11.

    Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999; 21: 163–167.

  12. 12.

    Taniguchi T, Schofield AE, Scarlett JL, Morison IM, Sullivan MJ, Reeve AE. Altered specificity of IGF2 promoter imprinting during fetal development and onset of Wilms tumour. Oncogene 1995; 11: 751–756.

  13. 13.

    Malcolm S, Clayton Smith J et al. Uniparental paternal disomy in Angelman’s syndrome. Lancet 1991; 337: 694–697.

  14. 14.

    Nicholls RD, Knoll JH, Butler MG, Karam S, Lalande M. Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome. Nature 1989; 342: 281–285.

  15. 15.

    Liang G, Salem CE, Yu MC et al. DNA methylation differences associated with tumor tissues identified by genome scanning analysis. Genomics 1998; 53: 260–268.

  16. 16.

    Gonzalgo ML, Hayashida T, Bender CM et al. The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res 1998; 58: 1245–1252.

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Pellicer, á. Methylation, an old/new player in the pathogenesis of neoplasia. Rev Oncología 2, 59–60 (2000). https://doi.org/10.1007/BF02979466

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