Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Anti-inflammatory activity of the major constituents ofLonicera japonica


Previously, we reported that then-butanol fraction ofLonicera japonica showed anti-inflammatrory activity in mice and rats. Several constituents such as loniceroside A and B, flavonoids and iridoids were isolated from this fraction. In this investigation, the anti-inflammatory activity of the major constituents ofL. japonica was studied. Loniceroside A, lonicerin and loganin showed anti-inflammatory activity comparable to aspirin.

This is a preview of subscription content, log in to check access.

References Cited

  1. Bhargava, K. P., Gupta, M. B., Gupta, G. P. and Mitra, C. R., Anti-inflammatory activity of saponins and other natural products.Indian J. Med. Res., 58, 724–730 (1970)

  2. Kawai, H., Kutoyanagi, M. and Ueno, A., Iridoid glucosides fromLonicera japonica Thunb.Chem. Pharm. Bull., 36, 3664–3666 (1988)

  3. Kim, H. K., Namgoong, S. Y. and Kim, H. P., Anti-inflammatory activity of flavonoids: Mice ear edema inhibition.Arch. Pharm. Res., 16, 18–24 (1993)

  4. Kubo, M., Matsuda, H., Tanaka, M., Nimura, Y., Okuda, H., Higashino, M., Tani, T., Namba, K. and Arichi, S., Studies on Scutellaria radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellaria radix.Chem. Pharm. Bull., 32, 2724–2729 (1984)

  5. Lee, S. J., Son, K. H., Chang, H. W., Kang, S. S., Park, P.-U., Kawk, W.-J., Han, C.-K. and Kim, H. P., Development of plant anti-inflammatory agents: Comparison of anti-inflammatory and analgesic activities of extracts fromLonicera japonica.Kor. J. Pharmacogn., 25, 363–367 (1994)

  6. Shanghai Science and Technologic Publisher and Shougakukan (1985) in The Dictionary of Chinese Drugs, Vol III, pp 2027–2029, Shougakukan, Tokyo.

  7. Son, K. H., Jung, K. Y., Chang, H. W., Kim, H. P. and Kang, S. S., Triterpenoid saponins from the aerial parts ofLonicera japonica.Phytochem., 35, 1005–1008 (1994a)

  8. Son, K. H., Kim, J. S., Kang, S. S., Kim, H. P. and Chang, H. W., Isolation of flavonoids fromLonicera japonica.Kor. J. Pharmacogn., 25, 24–27 (1994b)

  9. Son, K. H., Park, I. O., Chung, K. C., Chang, H. W., Kim, H. P., Kim, J. S. and Kang, S. S., Flavonoids from the aerial parts ofLonicera japonica.Arch. Pharm. Res., 15, 365–370 (1992)

  10. Tonnelli, G., Thiabault, L. and Ringler, I., A bioassay for the concomitent assessment of the antiphlogistic and thymolytic activities of topically applied corticoids.Endocrinol., 77, 625–634 (1965)

Download references

Author information

Correspondence to Hyun Pyo Kim.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, S.J., Shin, E.J., Son, K.H. et al. Anti-inflammatory activity of the major constituents ofLonicera japonica . Arch. Pharm. Res. 18, 133 (1995). https://doi.org/10.1007/BF02979147

Download citation

Key words

  • Lonicera japonica
  • n-butanol fraction
  • Anti-inflammatory activity
  • Loniceroside A
  • Lonicerin
  • Loganin