Previously, we reported that then-butanol fraction ofLonicera japonica showed anti-inflammatrory activity in mice and rats. Several constituents such as loniceroside A and B, flavonoids and iridoids were isolated from this fraction. In this investigation, the anti-inflammatory activity of the major constituents ofL. japonica was studied. Loniceroside A, lonicerin and loganin showed anti-inflammatory activity comparable to aspirin.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Bhargava, K. P., Gupta, M. B., Gupta, G. P. and Mitra, C. R., Anti-inflammatory activity of saponins and other natural products.Indian J. Med. Res., 58, 724–730 (1970)
Kawai, H., Kutoyanagi, M. and Ueno, A., Iridoid glucosides fromLonicera japonica Thunb.Chem. Pharm. Bull., 36, 3664–3666 (1988)
Kim, H. K., Namgoong, S. Y. and Kim, H. P., Anti-inflammatory activity of flavonoids: Mice ear edema inhibition.Arch. Pharm. Res., 16, 18–24 (1993)
Kubo, M., Matsuda, H., Tanaka, M., Nimura, Y., Okuda, H., Higashino, M., Tani, T., Namba, K. and Arichi, S., Studies on Scutellaria radix. VII. Anti-arthritic and anti-inflammatory actions of methanolic extract and flavonoid components from Scutellaria radix.Chem. Pharm. Bull., 32, 2724–2729 (1984)
Lee, S. J., Son, K. H., Chang, H. W., Kang, S. S., Park, P.-U., Kawk, W.-J., Han, C.-K. and Kim, H. P., Development of plant anti-inflammatory agents: Comparison of anti-inflammatory and analgesic activities of extracts fromLonicera japonica.Kor. J. Pharmacogn., 25, 363–367 (1994)
Shanghai Science and Technologic Publisher and Shougakukan (1985) in The Dictionary of Chinese Drugs, Vol III, pp 2027–2029, Shougakukan, Tokyo.
Son, K. H., Jung, K. Y., Chang, H. W., Kim, H. P. and Kang, S. S., Triterpenoid saponins from the aerial parts ofLonicera japonica.Phytochem., 35, 1005–1008 (1994a)
Son, K. H., Kim, J. S., Kang, S. S., Kim, H. P. and Chang, H. W., Isolation of flavonoids fromLonicera japonica.Kor. J. Pharmacogn., 25, 24–27 (1994b)
Son, K. H., Park, I. O., Chung, K. C., Chang, H. W., Kim, H. P., Kim, J. S. and Kang, S. S., Flavonoids from the aerial parts ofLonicera japonica.Arch. Pharm. Res., 15, 365–370 (1992)
Tonnelli, G., Thiabault, L. and Ringler, I., A bioassay for the concomitent assessment of the antiphlogistic and thymolytic activities of topically applied corticoids.Endocrinol., 77, 625–634 (1965)
About this article
Cite this article
Lee, S.J., Shin, E.J., Son, K.H. et al. Anti-inflammatory activity of the major constituents ofLonicera japonica . Arch. Pharm. Res. 18, 133 (1995). https://doi.org/10.1007/BF02979147
- Lonicera japonica
- n-butanol fraction
- Anti-inflammatory activity
- Loniceroside A