Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

The cell cycle and why is it important for oncology


  1. 1.

    Carnero A. Cell cycle and cancer. Rev Oncología 2000; 1: 12–22.

  2. 2.

    Motokura T, Bloom T, Kin HG, Jupner H, Ruderman JV, Kronenberg HH et al. A novel cyclin encoded by abcll-linked candidate oncogene. Nature 1991; 350: 512–515.

  3. 3.

    Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell 1991; 65: 691–699.

  4. 4.

    Matsushime S, Roussel MF, Ashmun RA, Sherr CJ. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 1991; 65: 701–713.

  5. 5.

    Lew DJ, Dulic V, Reed SI. Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast. Cell 1991; 66: 1197–1206.

  6. 6.

    Bosch F, Jares P, Campo E et al. PRAD-1/cyclin D1 gene overexpression in chronic lymphoproliferativedisorders: a highly specific marker of mantle cell lymphoma. Blood 1994; 84: 2726–2732.

  7. 7.

    Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993; 366: 704–707.

  8. 8.

    Quelle DE, Zindy F, Ashmun RA, Sherr CJ. Alternative reading frames of theINK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83: 993–1000.

  9. 9.

    Tetsu O, McCormick F. Β-Catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422–426.

  10. 10.

    Damalas A, Ben-Ze’ev A, Simcha I, Shtutman M, Martínez Leal JF, Zhurinsky J et al. Excess Β-catenin promotes accumulation of transcriptionally active p53. EMBO J 1999; 18: 3054–3063.

  11. 11.

    Guo M, Hay BA. Cell proliferation and apoptosis. Curr Opin Cell Biol 1999; 11: 745–752.

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Serrano, M. The cell cycle and why is it important for oncology. Rev Oncología 2, 1–2 (2000).

Download citation