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Cytotoxic constituents from Angelicae Sinensis radix

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Abstract

Cytotoxic bioassay-guided fractionation of methanol extract of Angelicae Sinensis Radix led to the isolation of a new dimericZ-ligustilide, named neodiligustilide (1), together with three known compounds,Z-ligustilide (2), 11(S),16(R)-dihydroxy-octadeca-9Z, 17-dien-12, 14-diyn-1-yl acetate (3), and 3(R), 8(S)-falcarindiol (4). Among them, 2 showed the strongest cytotoxicity against L1210 and K562 cell lines with IC50 values of 2.27 ± 0.10 and 4.78 ± 0.18 μM, respectively, while 1 showed moderate cytotoxicity with IC50 values of 5.45 ±0.19 and 9.87 ±0.14 μM. Two polyacetylenes, 3 and 4, showed cytotoxicity only against L1210 cell line with IC50 values of 2.60 ± 0.90 and 2.87 ± 0.49 μM, respectively.

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References

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Author information

Correspondence to Quart Cheng Chen or JongPill Lee or WenYi Jin or UiJoung Youn or HongJin Kim or Ik Soo Lee or XinFeng Zhang or KyungSik Song or YeonHee Seong or KiHwan Bae.

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Chen, Q.C., Lee, J., Jin, W. et al. Cytotoxic constituents from Angelicae Sinensis radix. Arch Pharm Res 30, 565–569 (2007). https://doi.org/10.1007/BF02977650

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Key words

  • Angelicae Sinensis Radix
  • Neodiligustilide
  • Cytotoxicity