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Effects of ß-glucan fromAureobasidium pullulans on acute inflammation in mice

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The effects of ß-glucan isolated fromAureobasidium pullulans were observed on acute xylene-induced inflammation, ß-glucan at a dose of 62.5, 125 or 250 mg/kg were administered once orally to xylene-treated mice (0.03 mL of xylene was applied on the anterior surface of the right ear to induce inflammation), and the body weight change, ear weight, histological profiles and histomorphometrical analyses of ear were conducted upon sacrifice. The xylene was topically applied 30min after dosing with ß-glucan. The results were compared to those of diclofenac, indomethacin and dexamethasone (15 mg/kg injected once intraperitoneally). All animals were sacrificed 2 h after xylene application. Xylene application resulted in marked increases in induced ear weights compared to that of intact control ear; hence, the differences between intact and induced ear were also significantly increased. The histological characteristics of acute inflammation, such as severe vasodilation, edematous changes of skin and infiltration of inflammatory cells, were detected in xylene-treated control ears with marked increase in the thickness of the ear tissues. However, these xylene-induced acute inflammatory changes were significantly and dose-dependently decreased by ß-glucan treatment. We conclude that ß-glu-can fromA. pullulans has a somewhat favorable effect in the reduction of the acute inflammatory responses induced by xylene application in mice.

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Correspondence to Hyeong-Dong Kim or Hyung-Rae Cho or Seung-bae Moon or Hyun-Dong Shin or Kun-Ju Yang or Bok-ryeon Park or Hee-Jeong Jang or Lin-Su Kim or Hyeung-Sik Lee or Sae-Kwang Ku.

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Kim, H., Cho, H., Moon, S. et al. Effects of ß-glucan fromAureobasidium pullulans on acute inflammation in mice. Arch Pharm Res 30, 323–328 (2007). https://doi.org/10.1007/BF02977613

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Key words

  • ß-Glucans
  • Aureobasidium pullulans
  • Acute inflammation
  • Histology
  • Mouse