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The antimicrobial activities of some 1,4-naphthalenediones (IV)

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A series of 2-chloro and 2-bromo-3-(substituted)-1,4-naphthalenedione derivatives (1–25) were tested for antifungal and antibacterial activitiesin vitro againstCandida albicans 10231 and Local,Aspergillus niger KCTC 1231,Tricophyton mentagrophytes KCTC 6085,Fusarium oxysporium KTCC 6051,Bacillus subtilis ATCC 6633,Pseudomonas aeruginosa NCTC 10490,Staphylococcus aureus ATCC 6538p,Escherichia coli NIHJ andAcinetobacter baumanii Local. The MIC values were determined by the twofold agar dilution/streak method. Among these derivatives, 1, 9, 20, 21, 23 and 25 showed more potent antifungal activities than fluconazole. 20 and 23 completely inhibited the growth of fungi, such asCandida albicans, Aspergillus niger, Tricophyton mentagrophytes andFusarium oxysporium, at 3.2 μg/ml. Also some derivatives had the antibacterial activities against Gram-positive bacteria.

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Correspondence to Chung -Kyu Ryu.

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Ryu, C.-., Kim, D.-., Kim, H.-. et al. The antimicrobial activities of some 1,4-naphthalenediones (IV). Arch. Pharm. Res. 16, 327 (1993). https://doi.org/10.1007/BF02977525

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Key words

  • 2-Chloro- and 2-bromo-3-substituted-1,4-naphthalenedione
  • MIC value
  • Antifungal
  • Antibacterial activities