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An efficient synthesis of risperidonevia stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist


Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tetrahydropyrido [1,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

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Correspondence to Jin-Hyun Jeong.

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Kim, D., Kang, M., Kim, J.S. et al. An efficient synthesis of risperidonevia stille reaction: Antipsychotic, 5-HT2, and dopamine-D2-antagonist. Arch Pharm Res 28, 1019–1022 (2005).

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Key words

  • Risperidone
  • Stille reaction
  • Synthesis
  • Antipsychotic
  • 5-HT2
  • Dopamine-D2-antagonist