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Immuno activation of lectin-conjugated praecoxin a on IL-6, IL-12 expression

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Abstract

Lectin-conjugated praecoxin A is a compound, which is combined Wheat Germ Agglutinin (WGA) Lectin with praecoxin A and also known to have an anti-tumor activity. In our lab, in order to investigate its immune reaction other than the anti-tumor activity ever known, we examined cytokines such as IL-6 and IL-12 through their mRNA expressions, which are generally secreted by macrophage bothin vivo andin vitro. To analyze, we used RT-PCR for total RNAs of macrophages. As a result, we obtained that bothin vitro andin vivo, lectin-conjugated praecoxin A showed an interesting increase on IL-6 and IL-12 even though it may be little hard to say the conjugated form is absolutely more effective than that of lectin or praecoxin A alone for immune response activities. Those results suggest that the conjugated form may give an additional opportunity in a future therapeutic use over its immuno activation properties.

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Author information

Correspondence to Seong -Soo Joo or Jae -Kwon Chang or Jeong -Hwan Park or Hee -Chul Kang or Do -Ik Lee.

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Joo, S.-., Chang, J.-., Park, J.-. et al. Immuno activation of lectin-conjugated praecoxin a on IL-6, IL-12 expression. Arch Pharm Res 25, 954–963 (2002). https://doi.org/10.1007/BF02977019

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Key words

  • Lectin-conjugated praecoxin A
  • Praecoxin A
  • IL-6
  • IL-12
  • Macrophage