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Anti-platelet effect of the constituents isolated from the barks and fruits ofMagnolia obovata


In the course of our work on anti-platelet constituents from plants, five phenolic compounds, mag-nolol, honokiol, obovatol, methyl caffeate, and syringin, were isolated from the methanol extracts of the barks and fruits ofMagnolia obovata. The compounds were identified based on the spectro-scopic data. Methyl caffeate was isolated for the first time from the genusMagnolia and it showed 3 – 4-folds higher potency than ASA. The activities of obovatol and honokiol were comparable to ASA. Magnolol and syringin showed only very mild inhibitory effects to all the stimulators.

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Correspondence to Mi Kyung Pyo or YongYook Lee or Hye Sook Yun-Choi.

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Pyo, M.K., Lee, Y. & Yun-Choi, H.S. Anti-platelet effect of the constituents isolated from the barks and fruits ofMagnolia obovata . Arch Pharm Res 25, 325 (2002). https://doi.org/10.1007/BF02976634

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Key word

  • Magnolia obovata
  • Methyl caffeate
  • Magnolol
  • Honokiol
  • Obovatol
  • Anti-platelet