The reaction of thiocyanoacetamide (1) with α,β-unsaturated ketones2a,b resulted in the formation of the corresponding newly synthesized 1(H)-pyridinethione derivatives3a,b. Compounds3a,b were used as synthons for the preparation of 2-S-alkyl-, 2-S-aryl, 2-S-acetamidopyridine, thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives via a wide range of reactions with different reagents. The antimicrobial activity of some of the newly synthesized compounds was tested. Compounds3a, 11a, 15a, and19a,b were found to be the most active ones.
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Attaby, F.A., Elneairy, M.A.A. & Elsayed, M.S. Synthesis and antimicrobial evaluation of new pyridine, thienopyridine and pyridothienopyrazole derivatives. Arch Pharm Res 22, 194–201 (1999). https://doi.org/10.1007/BF02976546
- Thieno[2,3-b]pyridine and pyrazolo[3,4-b]pyridine