Two neolignan compounds, magnolol (5,5′-diallyl-2,2′-dihydroxybiphenyl,1) and honokiol (5,5′-diallyl-2,4′-dihydroxybiphenyl,2), were isolated from the stem bark ofMagnolia obovata and evaluated for antifungal activity against various human pathogenic fungi. Compound1 and2 showed significant inhibitory activities againstTrichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, andCandida albicans with minimum inhibitory concentrations (MIC) in a range of 25–100 μg/ml. Therefore, compound1 and2 could be used as lead compounds for the development of novel antifungal agents.
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Bang, K.H., Kim, Y.K., Min, B.S. et al. Antifungal activity of magnolol and honokiol. Arch Pharm Res 23, 46–49 (2000). https://doi.org/10.1007/BF02976465
- Human pathogenic fungi
- Magnolia obovata