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Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts ofArtemisia montana

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The antioxidant activity ofArtemisia montana was determined by measuring the radical scavenging effect on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and inhibitory activity against free radical generation of hepatocytes (AC2F). The methanol extract ofA. montana showed strong radical scavenging activity at a concentration of 10.1 μg/ml, and thus fractionated by solvent extraction. Esculetin and luteolin 7-O-rutinoside (scolymoside) were isolated as the active principles from the EtOAc and Interphase fractions, respectively. The antioxidant activity of these compounds were comparable to that of L-ascorbic acid.

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Correspondence to Jae Sue Choi.

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Kim, N.M., Kim, J., Chung, H.Y. et al. Isolation of luteolin 7-O-rutinoside and esculetin with potential antioxidant activity from the aerial parts ofArtemisia montana . Arch Pharm Res 23, 237–239 (2000). https://doi.org/10.1007/BF02976451

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Key words

  • Artemisia montana
  • Esculetin
  • Luteolin 7-O-rutinoside
  • Antioxidant activity